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MetabolomicsMicrobiome-produced nicotinic acid controls colon regional identity and injury susceptibility

Regional structure of the intestinal epithelium is critical for its function and is associated with the risk of specific gut diseases. However, how regionalization is established and how it influences disease susceptibility remains poorly understood. Here, we investigated the role of the gut micr...

2026-03-27 | MTBLS12063 | MetaboLights
TranscriptomicsCircadian transcriptome of the mouse colon mucosa
In mammals circadian clocks are present not only in the hypothalamus but also in all peripheral organs where they rhytmically control tissue specific biological processes. Here, the transcriptome of the mouse colon mucosa was analysed around the clock to identify genes whose gne expression is under ...
ORGANISM(S): Mus musculus 
2014-03-18 | E-MTAB-1576 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of colon mucosa after cytotoxic insult in wild type and Apc-mutated rats: possible relation with resistance to apoptosis during carcinogenesis
Gene expression profiles of the colon mucosa of wild type and PIRC rats after 1,2-dimethylhydrazine (DMH)-treatment
ORGANISM(S): Rattus norvegicus 
2016-11-03 | E-MTAB-4910 | biostudies-arrayexpress
TranscriptomicsColon mucosa of F344 rats: control treated with 5% DSS vs Resveratrol + 5% DSS
Expression profile of colon mucosa of F344 rats treated with 5% DSS during five days vs colon mucosa of F344 rats pre-treated for 20 days with resveratrol 1mg/kg/day and during the five days of 5% DSS administration Keywords: Inflammation experiment Two conditions experiment, colon mucosa of F344 r...
ORGANISM(S): Rattus norvegicus 
2009-01-27 | E-GEOD-14544 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat colonic tumors induced by 1,2-dimethylhydrazine (DMH)
Gene expression analysis of 1,2-dimethylhydrazine (DMH)-induced colon cancer in F344 rats. 9 tumours and their paired normal mucosa were hybridized on 4x44K Agilent Whole rat arrays.
ORGANISM(S): Rattus norvegicus 
2010-07-20 | E-MEXP-2471 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of normal colon mucosa samples
To investigate whether lifestyle factors modulate the stability of gene promoter methylation in the normal aging colonic mucosa, we performed genome-scale DNA methylation profiling of 178 normal colon biopsies using the Illumina Infinium DNA methylation assay, which assesses the DNA methylation stat...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-48988 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of colon mucosa in wt and Apc-mutated Pirc rat
We evaluated the gene expression profiles of Pirc rats (mutated for the APC gene) at one month of age, prior to the development of visible preneoplastic tumors or lesions. The analysis was performed on both female and male animals, comparing Pirc rats with wild type F344 rats of the same age.
ORGANISM(S): Rattus norvegicus 
2021-07-30 | E-MTAB-10016 | biostudies-arrayexpress
ProteomicsMulti-Omics Characterization of Colon Mucosa and Submucosa/Wall from Crohn’s Disease Patients
Crohn’s disease (CD) is a subtype of inflammatory bowel disease (IBD) characterized by transmural disease. The concept of transmural healing (TH) has been proposed as an indicator of deep clinical remission of CD and as a predictor of favorable treatment endpoints. Understanding the pathophysiology ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050335 | Pride
Crohn’s disease  transmural healing  colon  mucosa  submucosa  wall  transcriptomics  proteomics  histology  isoform 
TranscriptomicsNormal mucosa of Proximal Colon (i.e. proximal to hepatic flexure) versus normal mucosa of Terminal ileum Transcriptomes (Affymetrix array U133A) in colon cancer patients
Proximal Colon (i.e. proximal to hepatic flexure) versus Terminal ileum Transcriptomes (Affymetrix array U133A). All subjects were operated on for proximal-colon tumor (biopsies of proximal-colon normal mucosa were made at more than 5 cm from the site of the tumor).
ORGANISM(S): Homo sapiens 
2021-03-03 | E-MTAB-10164 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat colon mucosa at different time points following Salmonella infection
Salmonella enteritidis is suggested to translocate in the small intestine. Previously we identified that prebiotics, fermented in the colon, increased Salmonella translocation in rats, suggesting involvement of the colon in translocation. Effects of Salmonella on colonic gene expression in vivo are ...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7496 | biostudies-arrayexpress
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