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MetabolomicsExercise-driven gut microbiota alterations enhance colonization resistance against methicillin-resistant Staphylococcus aureus

Gut microbiota plays a crucial role in resisting the invasion of pathogens, particularly multidrug-resistant (MDR) bacteria, which pose a significant threat to public health. While exercise offers numerous health benefits, its impact on host colonization resistance remains largely unclear. In thi...

2025-02-19 | MTBLS12219 | MetaboLights
MetabolomicsGut microbiota within-host evolution enforces colonization resistance against enteric infection

Limited resource availability in the gut promotes competitive interactions between bacteria, which drive adaptive within-host evolution. While the role of bacterial adaptive evolution of bacterial communities has been extensively studied, its functional implications for host physiology remain unk...

2026-08-03 | MTBLS10327 | MetaboLights
MetabolomicsMicrobiota-derived metabolites act as ecological effectors of colonization resistance against Salmonella Enteritidis

Colonization resistance is a fundamental ecological function of the gut microbiota that limits the expansion of enteric pathogens. Yet, the microbial effectors linking ecosystem homeostasis to pathogen control remain poorly understood. Here, we demonstrate that Salmonella Enteritidis (S. Enteriti...

2026-08-31 | MTBLS15505 | MetaboLights
MetabolomicsMetabolic network construction reveals probiotic-specific colonization resistance in a synthetic small intestinal community

The gut microbiota is essential to host health. Probiotics can be used as a microbiota targeted therapy to improve host health. However, probiotic molecular mechanisms of action and probiotics targeting the small intestinal microbiota are often not elucidated. In this study, we construct a three ...

2024-09-26 | MTBLS7370 | MetaboLights
MetabolomicsMeasuring SCFA in mice gut following colonization by C. difficile
Not available
ORGANISM(S): Mus musculus 
ST000734 | MetabolomicsWorkbench
TranscriptomicsAvian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
RNAseq analysis of caecal tissue from 14 C. jejuni-susceptible and 14 C. jejuni-resistant birds from a single population of infected chickens was conducted in order to identify gene expression associated with resistance to colonization. Significantly higher expression of genes involved in the innate...
ORGANISM(S): Gallus gallus 
2013-02-15 | E-GEOD-44341 | biostudies-arrayexpress
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15629 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15630 | MetaboLights
MetabolomicsPlants establish metabolic crosstalk with Pseudomonas for enhancing herbicide-stress resistance
Although it is known that plants can recruit beneficial rhizobacteria under various stresses, the mechanisms underlying their synergistic interaction in regulating plant resistance remain poorly understood. This study demonstrates that plants establish metabolic crosstalk with Pseudomonas for enhanc...
2026-09-12 | MTBLS15622 | MetaboLights
MetabolomicsArgR-dependent Bacterial Resistance to Host Lipid Droplets in Edwardsiella piscicida
Lipid droplets (LDs), as innate immune hubs, function in the front line of antimicrobial defense involved in the ongoing host-pathogen arms race. Particularly for intracellular bacterial pathogens, the endowed capacity to resist host LDs can effectively facilitate pathogen in vivo colonization and e...
2025-07-04 | MTBLS9590 | MetaboLights
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