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TranscriptomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [iTC-seq_drugs]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58018 | biostudies-arrayexpress
GenomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [ChIP-seq_Input]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58022 | biostudies-arrayexpress
TranscriptomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [RNA-seq_differentiation]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58017 | biostudies-arrayexpress
GenomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [ChIP-seq_drugs]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58019 | biostudies-arrayexpress
TranscriptomicsChromosome conformation capture on chip (4C) at the Fab7 polycomb response element in the bithorax complex of Drosophila
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of th...
ORGANISM(S): Drosophila melanogaster 
2010-12-31 | E-GEOD-23887 | biostudies-arrayexpress
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