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TranscriptomicsInhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model [mRNA]
Chromatin acetylation is attributed with distinct functional relevance with respect to gene expression in normal and diseased conditions thereby leading to a topical interest in the concept of epigenetic modulators and therapy. We report here the identification and characterization of the acetylatio...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-75029 | biostudies-arrayexpress
ProteomicsSite-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags
Protein kinases are prime targets for drug development due to their involvement in various cancers. However, selective inhibition of kinases, while avoiding off-target effects remains a significant challenge for the development of protein kinase inhibitors. Activity-based protein profiling (ABPP), i...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058749 | Pride
Chemical proteomics  activity-based protein profiling  site-specific  protein kinase inhibitor profiling  ephrin receptor inhibitor  nvp-bhg712 
GenomicsCompetitive Inhibition and Mutualistic Growth in Polymicrobial Infections: Deciphering Staphylococcus aureus – Acinetobacter baumannii Interaction Dynamics
Competitive Inhibition and Mutualistic Growth in Polymicrobial Infections: Deciphering Staphylococcus aureus – Acinetobacter baumannii Interaction Dynamics
PRJNA1052741 | ENA
UnknownMixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model.
Not available
S-EPMC10683834 | biostudies-literature
UnknownDevelopment of directed global inhibition, competitive inhibition and behavioural inhibition during the transition between infancy and toddlerhood.
Not available
S-EPMC11475536 | biostudies-literature
UnknownCalcium Competitive Inhibition of Langerin by Thiazolopyrimidinones.
Not available
S-EPMC7618453 | biostudies-literature
TranscriptomicsGene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor
We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40971 | biostudies-arrayexpress
UnknownMolecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition.
Not available
S-EPMC9779292 | biostudies-literature
UnknownDeviance detection via competitive inhibition between local neocortical ensembles.
Not available
S-EPMC11741386 | biostudies-literature
ProteomicsIsocyanides inhibit bacterial pathogents by covalent targeting of essential metabolic enzymes
Isonitrile (also termed isocyanide) natural products exhibit potent antimicrobial activities, but little is known about their molecular targets. Here, we focus on the so far neglected group of monoisonitriles to gain further insights into their antimicrobial mode of action (MoA). Screening a focused...
ORGANISM(S): Staphylococcus aureus 
2024-06-26 | PXD050437 | Pride
Antibiotics Sar Moa studies Target identification Isocyanide Covalent inhibitors 
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