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TranscriptomicsComplement Factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.
Purpose: The complement system is closely linked to the pathogenesis of age-related macular degeneration (AMD). Several complement genes are expressed in retinal pigment epithelium (RPE), and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers inc...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-38671 | biostudies-arrayexpress
MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
ProteomicsFactor H and related proteins in AMD
Age-related macular degeneration (AMD) is a common form of adult blindness. Risk of developing AMD is strongly linked to genetics, in particular at the Regulators of Complement Activation (RCA) locus on Chr1, which contains 6 genes, Complement Factor H (CFH) and Complement Factor H-related 1-5 (CFHR...
ORGANISM(S): Homo Sapiens 
2022-01-18 | PXD023466 | panorama
ProteomicsThioredoxin reduces complement factor H and alters its complement regulatory function
Complement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and C...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD009558 | Pride
Complement factor h Thioredoxin Disulfide bonds 
GenomicsExpression data from monocytes treated with complement factor H
Expression data from monocytes treated with complement factor H
PRJNA532421 | ENA
ProteomicsReduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation
This dataset contains cross-linking data of the complement factor H cross-linked to the apoE2 N-terminal fragment using DSS-H12/D12.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-12 | MSV000091051 | MassIVE
GenomicsComplement Factor H maintains macrophage homeostasis through TRPM7 signaling
Complement Factor H maintains macrophage homeostasis through TRPM7 signaling
PRJNA1170995 | ENA
ProteomicsReduced binding of apolipoprotein E4 isoform to complement factor H promotes amyloid-beta induced neuroinflammation
Brain total lysate from ad patient. Reduced binding of apolipoprotein E4 isoform to complement factor H promotes amyloid-beta induced neuroinflammation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-27 | MSV000088618 | MassIVE
ProteomicsProof of concept a new plasma complement Factor H from waste plamsa fraction
Introduction: Complement factor H (FH) is a major regulator of the complement alternative pathway, its mutations predispose to an uncontrolled activation in the kidney and on blood cells and to secondary C3 deficiency. Plasma exchange has been used to correct for FH deficiency and although the thera...
ORGANISM(S): Homo sapiens (Human) 
2024-03-27 | PXD050268 | Pride
Concentrated complement factor h  plasma purification 
ProteomicsNitration of Tyrosines In Complement Factor H Domains Alters Its Immunological Activity and Mediates A Pathogenic Role In Age Related Macular Degeneration
Nitrosative stress has been implicated in the pathogenesis of age related macular degeneration (AMD). Tyrosine nitration is a unique type of post translational modification that occurs in the setting of inflammation and nitrosative stress. To date, the significance and functional implications of tyr...
ORGANISM(S): Homo sapiens (Human) 
2017-08-29 | PXD005613 | Pride
Complement factor h Nitrotyrosine Cfh Macular degeneration 
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