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MetabolomicsCardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy
Succinate dehydrogenase, which is known as mitochondrial complex II, has proven to be a fascinating machinery, attracting renewed and increased interest in its involvement in human diseases. Herein, we find that succinate dehydrogenase assembly factor 4 (SDHAF4) is downregulated in cardiac muscle in...
2022-08-12 | MTBLS4579 | MetaboLights
MetabolomicsMetabolite profile data of grapevine plants with brown wood streaking and grapevine leaf stripe (esca complex disease) symptoms

Leaf samples were obtained from Vitis vinifera ‘Malvasia Fina’ plants with well-characterized esca complex disease symptoms (n = 18) and from healthy uninfected plants (n = 6). Leaves from diseased plants were divided into three groups: asymptomatic (ASY), chlorotic (SY1), and scorched leaves (SY...

2021-11-21 | MTBLS353 | MetaboLights
ProteomicsAtomic structures of respiratory complex III2 complex IV and supercomplex III2-IV from vascular plants
Mitochondrial complex III (CIII2) and complex IV (CIV) which can associate into a higher-order supercomplex (SC III2 IV) play key roles in respiration. However, structures of these plant complexes remain unknown. We present atomic models of CIII2, CIV and SC III2 IV from Vigna radiata determined by ...
ORGANISM(S): Vigna Radiata (ncbitaxon:157791) 
2020-10-05 | MSV000086237 | MassIVE
MetabolomicsOnline Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted volatile metabolomics for studying emerging complex biopesticides: A proof of concept
This work introduces a novel online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted metabolomics approach, suggested as an alternative tool to study the environmental fate of volatile xenometabolites in emerging complex biopesticides, e.g. the Myrica gale ...
2021-01-26 | MTBLS2026 | MetaboLights
ProteomicsPathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury
Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM antibodies recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14862 | biostudies-arrayexpress
ProteomicsHuman Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV
Human Tim8a and Tim8b are paralogous intermembrane space proteins of the small TIM chaperone family. Yeast small TIMs function in the trafficking of proteins to the outer and inner mitochondrial membranes. This putative import function for hTim8a and hTim8b has been challenged in human models, but t...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037906 | Pride
Small tims Protein trafficking Mitochondria Protein assembly Complex iv 
ProteomicsStructural variation of types IV-A1- and IV-A3-mediated CRISPR interference
CRISPR-Cas mediated DNA-interference typically relies on sequence-specific binding and nucleolytic degradation of foreign genetic material. Type IV-A CRISPR-Cas systems diverge from this general mechanism, using a nuclease-independent interference pathway to suppress gene expression for gene regulat...
ORGANISM(S): Pseudomonas oleovorans 
2024-10-08 | PXD056399 | Pride
Cryo-em Type iv crispr-cas 
GenomicsSMIM20 promotes complex IV biogenesis and Ca2+ Signalling in mice heart
SMIM20 promotes complex IV biogenesis and Ca2+ Signalling in mice heart
PRJNA1188571 | ENA
TranscriptomicsDipeptidyl peptidase-IV is associated with decreased glioma growth
Effect of expression of dipeptidyl peptidase-IV (DPP-IV) in U373 cell line on uncontrolled cell proliferation and aberrant interactions with the brain extracellular matrix.
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MTAB-583 | biostudies-arrayexpress
ProteomicsLysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen a1a1a2(IV)
We performed proteomic identification of type IV collagen gel bands from wild-type and lysyl hydroxylase 3 knockout cells by LC-MS after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2022-11-21 | PXD035051 | JPOST Repository
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