Sort   by:  
 Page size 
0
GenomicsA Case-Controlled Study for Genotype-Phenotype Associations in Multiple Sclerosis (MS)

This is a multi-centre, case-controlled study to develop a dataset containing 1000 MS cases and 1000 matched controls and to associate DNA sequence (allelic) variations with MS phenotypes.

Study subjects were enrolled through a prospective effort initiated in 2003. Three MS clinical cent...

phs000171.v1.p1 | EGA
0
TranscriptomicsTranscription profiling of human peripheral blood from relapsing-remitting MS patients either untreated or treated with glatiramer acetate or interferon beta
One of our new major finding among the genes that contributes to MS susceptibility is ICSBP1. The so called disease modifyi...
... disease modyfing treatment (Interferon Beta and Glatiramer Acetate), in order to correlate gene expression and genotype data and in order to identify sets of genes specifically regulated in the different treatment categories. Experiment Overall Design: Between July 2002 and October 2007, PBMC samples were collected from relapsing-remitting MS subjects and CIS subjects as part of the Comprehensive Longitudinal Investigation of MS at the Brigham & Women’s Hospital (CLIMB study). We then selected the first time point for each subject with multiple measurements based on an at least three months of treatment criteria. We thereafter analyzed the data for each treament category.
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-16214 | biostudies-arrayexpress
0
UnknownMapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
Not available
S-EPMC2773992 | biostudies-literature
0
GenomicsInternational Multiple Sclerosis Genomics Consortium (IMSGC) Genome Wide Association Study of Multiple Sclerosis

The goal of this study is to perform a comprehensive allelic and genotypic association analysis of t...
...nkage disequilibrium relationships among SNPs to further increase power (e.g. haplotype analysis). Quality control and data analysis are significant challenges. We will initially perform substantial QC checks and analyze the data using both TDT and AFBAC approaches. Multigenic interactions will also be tested using MDR.

phs000139.v1.p1 | EGA
0
UnknownA non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.
Not available
S-EPMC2946966 | biostudies-literature
0
UnknownA major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
Not available
S-EPMC2892470 | biostudies-literature
0
UnknownA "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.
Not available
S-EPMC3655974 | biostudies-literature
1K
OtherWellcome Trust Case Control Consortium
The Wellcome Trust Case Control Consortium (WTCCC) is a collaboration of 24 leading human geneticists, who will analyse thousands of DNA samples from patients suffering with different diseases to identify common genetic variations for each condition.
EGAO00000000001 | EGA
0
UnknownThe role of the CD58 locus in multiple sclerosis.
Not available
S-EPMC2664005 | biostudies-literature
1K
Other1958 British Birth Cohort
The National Child Development Study (NCDS) - also known as the 1958 British Birth Cohort (1958BC) - is a conti...
...d widely for research in genetic and genomic epidemiology - in particular as a platform for genetic association studies. Data are released under various Data Access Agreements. (1) Data users requesting genotype dat...
EGAO00000000016 | EGA
Sort   by:  
 Page size