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TranscriptomicsChromatin immunoprecipitation of mouse and human cell lines and tissues using E2F4 antibodies
Despite being expressed in most tissues, a number of mammalian process-specific transcriptional regulators, such as those involved in cell cycle and immune responses, often have profound tissue-specific phenotypes. The mechanism underlying this effect is poorly understood. We chose to investigate ...
ORGANISM(S): Mus musculus 
2007-07-05 | E-TABM-272 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine where genetic sequence or nuclear environment directs tissue specific-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 to determine whether human genetic se...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-474 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine whether genetic sequence or nuclear enviornment directs tissue-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 (TC1) to determine whether human gene...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-473 | biostudies-arrayexpress
GenomicsGenentech Colon Cancer Screen
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alte...
EGAS00001000288 | EGA
GenomicsColon_Illumina_2.5M_Controls - samples
Colon matched tumour samples
EGAD00010000274 | EGA
GenomicsColon_Illumina_2.5M_Cases - samples
Colon tumour samples
EGAD00010000272 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:54:35:559-18 - samples
Exome capture sequencing of colon tumor/normal pairs
EGAD00001000216 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:45:02:785-17 - samples
RNA sequencing of colon tumor/normal sample pairs
EGAD00001000215 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:36:55:498-15 - samples
Whole genome sequencing of colon samples
EGAD00001000214 | EGA
GenomicsGenentech Data Access Committee
Data Access Committee EGAC00001000055
EGAC00001000055 | EGA
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