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GenomicsIdentification of Cux2 binding sites in female and male mouse liver
Growth hormone (GH)-regulated transcription factors, notably STAT5 and BCL6, play a major role in regulating genes showing sex differences in expression in mouse liver, primarily through their effects in male liver, where male-biased genes are up regulated and many female-biased genes are actively r...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-35985 | biostudies-arrayexpress
GenomicsIdentification of Hnf6 binding sites in male and female mouse liver
∼40,000 HNF6 binding sites were identified in mouse liver chromatin, including several thousand sites showing significant differences in level of HNF6 binding between male and female mouse liver. These sex-biased HNF6 binding sites showed strong enrichment for sex-biased DNase hypersensitive sites a...
ORGANISM(S): Mus musculus 
2015-07-28 | E-GEOD-60014 | biostudies-arrayexpress
TranscriptomicsImpact of Cux2 knockdown on gene expression in female mouse liver (Mus musculus)
We identified genes expressed in mouse liver that are regulated by Cux2, a highly female-specific liver transcription factor whose expression is regulated by sex-dependent plasma GH patterns. Using siRNA to knockdown Cux2 expression in female liver, we show that female specific genes are predominan...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-37078 | biostudies-arrayexpress
TranscriptomicsImpact of Cux2 overexpression on gene expression in male and female mouse liver (Mus musculus)
We identified genes expressed in mouse liver that are regulated by Cux2, a highly female-specific liver transcription factor whose expression is regulated by sex-dependent plasma GH patterns. Using adenovirus to overexpress Cux2 (Adeno-Cux2) in male liver, we show that Cux2 represses ~35% of male-b...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-35897 | biostudies-arrayexpress
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