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ProteomicsSerum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome
In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in babies who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIK...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020294 | Pride
Zika virus Czs Serum 
ProteomicsMulti-omics approach reveals serum biomarker candidates for Congenital Zika Syndrome
During pregnancy, the Zika virus (ZIKV) can be vertically transmitted, causing Congenital Zika Syndrome (CZS) in fetuses. ZIKV infection in early gestational trimesters increases the chances to develop CZS. This syndrome involves several pathologies with a difficult diagnosis, which usually occurs i...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD043324 | Pride
Zika virus  proteomics  metabolomics  multi-omics  congenital zika syndrome  microcephaly  serum  biomarkers 
ProteomicsGlycerophospholipid and amino acid metabolism impairment during Congenital Zika Syndrome development
Zika virus (ZIKV) can be transmitted vertically to the fetus, having a high chance to develop Congenital Zika Syndrome (CZS). Studies have shown that ZIKV impairs brain development. However, little is known about the molecular differences between non- microcephalic ZIKV-infected fetuses and microcep...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD039643 | Pride
Metabolomics Congenital zika syndrome Amino acid metabolism Zika virus Glycerophospholipid metabolism Amniotic fluid 
TranscriptomicsRNA-seq of hiPSCs-derived NPCs from 3 pairs of dizygotic discordant twins for Congenital Zika syndrome
Congenital Zika syndrome (CZS), caused by Zika virus (ZIKV) infection, has been associated to impairment of early brain development, particularly related to neural progenitor cells (NPCs) survival and growth. In this work we report in a high-throughput manner (RNA-Seq) the differences in the transcr...
ORGANISM(S): Homo sapiens 
2018-02-27 | GSE102128 | GEO
UnknownWhat are the implications of Zika Virus for infant feeding? A synthesis of qualitative evidence concerning Congenital Zika Syndrome (CZS) and comparable conditions.
Not available
S-EPMC7605709 | biostudies-literature
GenomicsMolecular Alterations of Extracellular Matrix in the Brain of Newborns with Congenital Zika Syndrome
Molecular Alterations of Extracellular Matrix in the Brain of Newborns with Congenital Zika Syndrome
PRJNA516806 | ENA
TranscriptomicsMolecular Alterations of Extracellular Matrix in the Brain of Newborns with Congenital Zika Syndrome
Zika virus (ZIKV) infection during pregnancy could cause a set of severe abnormalities in the fetus known as congenital Zika syndrome (CZS). Experiments using animal models and in vitro systems significantly contributed to our understanding of the physiopathology of ZIKV infection. However, the mole...
ORGANISM(S): Homo sapiens 
2020-05-18 | GSE125554 | GEO
ProteomicsAmniotic fluid proteomics in Congenital Zika Syndrome
In this study, we analyzed by a shotgun proteomic approach the amniotic fluid of pregnant women infected with Zika carrying microcephalic (ZIKV+M+) or healthy fetuses (ZIKV+M-) compared to Zika negative controls (ZIKV-M-) to identify and understand the biological process and pathways affected by CZS...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD023776 | Pride
Zika virus  proteomics  microcephaly  amniotic fluid  neutrophil degranulation  extracellular matrix 
ProteomicsProteomic profiles of ZIKV-positive placentas of fetuses with microcephaly
Here we use a proteomic approach to study the role of the placenta in ZIKV-induced microcephaly and the mechanisms of ZIKV to cross the placental barrier. Samples were separated into three groups: an uninfected control group (ZIKV-CZS-), a group of placentas infected by ZIKV with normal neonates (ZI...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD023777 | Pride
Zika virus  proteomics  microcephaly  placenta  immune response  congenital zika syndrome 
GenomicsZIKV infection of a hiPSC-NPC line derived from a Congenital ZIKV Syndrome (CZS)-affected patient
ZIKV infection of a hiPSC-NPC line derived from a Congenital ZIKV Syndrome (CZS)-affected patient
PRJNA1171847 | ENA
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