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MetabolomicsDetailed Profiling of 17-Hydroxygeranyllinalool Diterpene Glycosides from Nicotiana Species Reveals Complex Reaction Networks of Conjugation Isomers

Background: Specialised anti-herbivory metabolites are abundant in the solanaceous genus Nicotiana. These metabolites include the large family of 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs). Many HGL-DTGs occur exclusively within the Nicotiana genus,...

2026-02-04 | MTBLS13756 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Lipidome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-21 | MTBLS578 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Metabolome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-17 | MTBLS577 | MetaboLights
ProteomicsSite-Selective Protein Conjugation by a Multicomponent Ugi Reaction
The chemical bioconjugation of proteins has seen tremendous applications in the past decades, with the booming of antibody-drug conjugates and their use in oncology. While genetic engineering has permitted to produce bespoke proteins featuring key (un-)natural amino acid residues poised for site-sel...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD045387 | Pride
Biomolecule  site conjugation  chemical biology  peptide mapping 
TranscriptomicssRNA profiling during Oxytricha conjugation
In Oxytricha, the somatic genome is responsible for vegetative growth, while the germline contributes DNA to the next sexual generation. Somatic nuclear development eliminates all transposons and other so-called "junk DNA", which constitute ~95% of the germline. We demonstrate that Piwi-in...
ORGANISM(S): Oxytricha trifallax 
2012-09-01 | E-GEOD-40081 | biostudies-arrayexpress
GenomicsConjugation-based genome engineering in Deinococcus radiodurans
Conjugation-based genome engineering in Deinococcus radiodurans
PRJEB48130 | ENA
TranscriptomicsComparative RNA expression analysis of Arabidopsis leaf material differing in genes of SUMO conjugation
SUMO conjugation is an important process in developmental transitions and in environmental stress responses. We generated mutants in the key enzyme SUMO conjugating enzyme 1 of Arabidopsis thaliana and investigated how these mutations affect gene expression in leaves. We also combined mutations in S...
ORGANISM(S): Arabidopsis thaliana 
2026-09-01 | E-MTAB-17503 | biostudies-arrayexpress
ProteomicsConjugation site characterization of antibody–drug conjugates using electron-transfer/higher-energy collision dissociation (EThcD)
Antibody–drug conjugates (ADCs) are formed by binding of cytotoxic drugs to monoclonal antibodies (mAbs) through chemical linkers. A comprehensive evaluation of the critical quality attributes (CQAs) of ADCs is vital for drug development but remains challenging owing to ADC structural heterogeneity ...
ORGANISM(S): Homo Sapiens 
2023-02-14 | PXD040111 |
GenomicsHigh-Throughput Conjugation in Escherichia coli
High-Throughput Conjugation Reveals Strain Specific Recombination Patterns Enabling Precise Trait Mapping in Escherichia coli
PRJEB85334 | ENA
ProteomicsTreatment with Cefotaxime Affects Expression of Conjugation Associated Proteins and Conjugation Transfer Frequency of an IncI1 Plasmid in Escherichia coli
Horizontal gene transfer (HGT) is the major mechanism responsible for spread of antibiotic resistance. Antibiotic treatment has been suggested to promote HGT, either by directly affecting the conjugation process itself or by selecting for conjugations subsequent to DNA transfer. However, recent rese...
ORGANISM(S): Escherichia coli 
2017-11-21 | PXD006679 | Pride
Antibiotics Proteomics Escherichia coli Itraq 
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