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MetabolomicsProteomic and metabolic changes in cancer cells after alternation of SHMT2 expressions
In order to understand the underline mechanism of SHMT2 (serine hydroxymethyltransferase 2) effect on tumor growth, proteome and metabolome analysis were carried on an engineered HeLa cell line (HeLa-SHMT2-shSHMT2, short as HeLa-Ss), which has inducible SHMT2 over-expression or suppression by treati...
2020-08-20 | MTBLS405 | MetaboLights
MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
ProteomicsTransfection with Glucuronidase A affects general proteome pattern in Giardia lamblia trophozoites
Giardia lamblia is an important causative agent of persistent diarrhea in humans, domestic animals, and cattle. Basic research is usually performed with the strain WBC6 and includes genetic manipulations such as transfections. Here, we investigate how transfection with a plasmid causing stable expre...
ORGANISM(S): Giardia intestinalis assemblage B 
2021-01-07 | PXD022565 | Pride
Controls and standards in proteomic experimental procedures  model organisms  reverse genetics  untargeted proteomics 
ProteomicsMulti-omics Characterization of NIST Seafood Reference Materials
The National Institute of Standards and Technology (NIST) has prepared four seafood reference materials (RMs) for use in food safety and nutrition studies: wild-caught and aquacultured salmon (RM 8256 and RM 8257) and wild-caught and aquacultured shrimp (RM 8258 and RM 8259). These materials were ch...
ORGANISM(S): Oncorhynchus Kisutch (ncbitaxon:8019) Penaeoidea (ncbitaxon:111520) 
2023-08-21 | MSV000092716 | MassIVE
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
MetabolomicsElevated CO2 and virus infection impacts wheat and aphid metabolism

INTRODUCTION: The aphid Rhopalosiphum padi L. is a vector of Barley yellow dwarf virus (BYDV) in wheat and other economically important cereal crops. Increased atmospheric CO2 has been shown to alter plant growth and metabolism, enhancing BYDV disease in wheat. However, the bioch...

2019-01-16 | MTBLS622 | MetaboLights
ProteomicsQuantitative proteomics with Regen V standardization of PTEN deletion-induced optic nerve regeneration mouse models and controls.
A quantitative proteomic profiling was performed on PTEN deletion-induced optic nerve regeneration mouse models and controls. At postnatal day 28 (week 4), PTENloxP/loxP mice were subjected to intravitreal injection (2-3ul) of adeno-associated viruses expressing Cre (AAV2-Cre) or control placenta al...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-27 | MSV000093512 | MassIVE
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
ProteomicsQuantitative proteomics with Regen V standardization in axon regeneration of Xenopus Laevis.
In this labeled quantitative proteomics dataset we profile the proteomic changes in a transgenic line of 1 year old Xenopus laevis Tg(islet2bgfp) frogs that were left untreated (naive) or had a monocular surgery of either a left optic crush injury (crush) or a sham surgery. Matching controls of unin...
ORGANISM(S): Xenopus Laevis (ncbitaxon:8355) 
2023-11-22 | MSV000093465 | MassIVE
MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
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