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UnknownStructural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.
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S-EPMC5512059 | biostudies-literature
UnknownTo blind or not to blind first in human and exploratory clinical trials: Acceleration of development vs. risk of bias.
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S-EPMC8932719 | biostudies-literature
UnknownBarth syndrome: an X-linked cause of fetal cardiomyopathy and stillbirth.
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S-EPMC2995309 | biostudies-literature
UnknownIdentification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.
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S-EPMC3506127 | biostudies-literature
UnknownRadiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial.
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S-EPMC6319250 | biostudies-literature
UnknownFluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery.
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S-EPMC10163929 | biostudies-literature
UnknownChildhood, adolescent, and young adulthood cancer risk in BRCA1 or BRCA2 pathogenic variant carriers.
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S-EPMC11972678 | biostudies-literature
UnknownSocial Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study.
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S-EPMC6178963 | biostudies-literature
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
UnknownThe impact of inversions across 33,924 families with rare disease from a national genome sequencing project.
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S-EPMC11179413 | biostudies-literature
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