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TranscriptomicsAn epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-33072 | biostudies-arrayexpress
TranscriptomicsSubstitutions in the KRas oncogene determine protein behavior: Implications for signaling and clinical outcome.
Mutant KRAS (mut-KRAS) is present in 30% of all human cancers and plays a critical role in cancer cell growth and resistance to therapy. There is evidence from colon cancer that mut-KRAS is a poor prognostic factor and negative predictor of patient response to molecularly targeted therapy. However,...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-27389 | biostudies-arrayexpress
UnknownFinal efficacy and biomarker analysis of the sorafenib arm of the BATTLE (Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination) trial
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-31428 | biostudies-other
TranscriptomicsFinal efficacy and biomarker analysis of the sorafenib arm of the BATTLE (Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination) trial
Purpose: To determine the 8-week disease control rate (DCR) of sorafenib monotherapy in patients with advanced non-small-cell lung cancer (NSCLC) in the BATTLE trial. Methods: Patients with pre-treated NSCLC consented to baseline biopsies for pre-specified biomarkers assessment and biomarker discove...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-31428 | biostudies-arrayexpress
UnknownSubstitutions in the KRas oncogene determine protein behavior: Implications for signaling and clinical outcome
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-27389 | biostudies-other
TranscriptomicsAn EGFR-mutation signature reveals features of the EGFR-dependent phenotype and identifies MACC1 as an EGFR-associated regulator of MET.
EGFR-mutated non-small cell lung cancers bear hallmarks including sensitivity to EGFR inhibitors, and low proliferation, and increased MET. However, the biology of EGFR dependence is still poorly understood. Using a training cohort of chemo-naive lung adenocarcinomas, we have developed a 72-gene s...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-31852 | biostudies-arrayexpress
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