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MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsTranscriptome modulation of ventricles, cardiomyocytes and cardiac fibroblasts during postnatal mouse development
During development the fetal heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). We performed deep RNA-sequencing for high-resolution analysis of transcriptome changes during postnatal mou...
ORGANISM(S): Mus musculus 
2014-04-16 | E-GEOD-49906 | biostudies-arrayexpress
TranscriptomicsMyotonic dystrophy type 1 (DM1) leads to altered mRNA expression in heart tissue
Myotonic dystrophy type 1 (DM1) is a dominantly inherited disease that affects multiple organ systems. Cardiac dysfunction is the second leading cause of death in DM1. We quantified gene expression in heart tissue from a heart-specific DM1 mouse model (EpA960/MCM) which inducibly expresses human DMP...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-48991 | biostudies-arrayexpress
UnknownEnhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion.
Not available
S-EPMC6200597 | biostudies-literature
UnknownStudy protocol for a randomised controlled trial assessing the clinical and cost-effectiveness of the Journeying through Dementia (JtD) intervention compared to usual care.
Not available
S-EPMC6747651 | biostudies-literature
GenomicsEGAS00001000165-sc-20150427 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001353 | EGA
GenomicsEGAS00001000902-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001351 | EGA
GenomicsEGAS00001000160-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001349 | EGA
GenomicsFrequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm and the mitochondrial double membrane. Despite these physical barriers we show that somatically acquired mitochondrial-nuclear genome fusion sequences are pres...
EGAS00001001234 | EGA
UnknownAccelarated immune ageing is associated with COVID-19 disease severity.
Not available
S-EPMC10782727 | biostudies-literature
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