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ProteomicsA versatile bacterial innate immunity protein directly senses two unrelated phage proteins (HDX-MS)
Eukaryotic innate immune systems use pattern recognition receptors (PRRs) to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense certain components of their viral predators known as ...
ORGANISM(S): Escherichia coli BW25113 
2025-05-13 | PXD050526 | Pride
Hdx ms 
ProteomicsActivation of a bacterial immunity protein by a viral-host factor complex (HDX-MS)
Bacteria have developed sophisticated immune systems to defend against phages, often activating these defenses by detecting specific phage components. In our study, we show that the bacterial defense protein CapRelEbc is activated by a complex between a T7 phage protein (Gp0.4) and the host’s cell d...
ORGANISM(S): Escherichia coli (strain B / BL21) 
2026-04-29 | PXD065182 | Pride
Hdx-ms Anti-phage defense 
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