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TranscriptomicsInflammatory mediators alter astrocyte genomic profiles and G-protein receptor evoked calcium signaling
Inflammation features in diverse central nervous system disorders such as stroke, trauma, neurodegeneration, infection and autoimmunity. To better understand how inflammatory mediators may alter astrocyte functions, we examined the effects of transforming growth factor-β1 (TGF-β1), lipopolysacchar...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-36089 | biostudies-arrayexpress
TranscriptomicsSprouting transcriptome in cortical neurons
This SuperSeries is composed of the following subset Series: GSE24440: Sprouting transcriptome in cortical neurons: young GSE24441: Sprouting transcriptome in cortical neurons: aged Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24442 | biostudies-arrayexpress
TranscriptomicsFunctional genomic analysis of frataxin deficiency
This SuperSeries is composed of the following subset Series: GSE15843: Functional genomic analysis of frataxin deficiency, Agilent data GSE15848: Functional genomic analysis of frataxin deficiency, Illumina data Refer to individual Series
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-15849 | biostudies-arrayexpress
GenomicsSpecific and behaviorally consequential astrocyte G q GPCR signaling attenuation in vivo with iβARK
Specific and behaviorally consequential astrocyte G q GPCR signaling attenuation in vivo with iβARK
PRJNA666885 | ENA
TranscriptomicsRobust axonal regeneration occurs in the injured CAST/Ei mouse central nervous system
Axon regeneration in the central nervous system (CNS) requires reactivating injured neurons’ intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on C...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-67130 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet-repeat disorders characterized by movement deficits and cognitive dysfunction. Although the mechanisms contributing to the gene expression deficits remain unknown, therapeutic ...
ORGANISM(S): Mus musculus 
2010-12-27 | E-GEOD-26317 | biostudies-arrayexpress
TranscriptomicsGene Expression Study in WT and ATF4 KO embryonic neurons
Oxidative stress is pathogenic in neurological diseases including stroke. The identity of oxidative stress-inducible transcription factors and their role(s) in propagating the death cascade are poorly understood. Microarray analysis of neurons undergoing oxidative stress showed significant induction...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-10470 | biostudies-arrayexpress
TranscriptomicsGene expression study in choroid plexus
The choroid plexus (CP) constitutes one of the blood–brain barriers – the blood cerebrospinal fluid barrier. It is formed by a monolayer of epithelial cells located within the brain ventricles and in addition to be responsible for the formation of the cerebrospinal fluid (CSF) is ideally positioned ...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-23714 | biostudies-arrayexpress
TranscriptomicsProspective Identification, Isolation, and Profiling of a Telomerase-Expressing Subpopulation of Human Neural Stem Cells, using sox2 Enhancer-Directed Fluorescence-Activated Cell Sorting
Sox2 is expressed by neural stem and progenitor cells, and a sox2 enhancer identifies these cells in the forebrains of both fetal and adult transgenic mouse reporters. We found that an adenovirus encoding EGFP placed under the regulatory control of a 0.4 kb sox2 core enhancer selectively identified ...
ORGANISM(S): Homo sapiens 
2011-02-25 | E-GEOD-27505 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [04_Cerebellun_and_brain]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Mus musculus 
2014-09-15 | E-GEOD-61324 | biostudies-arrayexpress
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