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UnknownCellular and Molecular Determinants of Biologic Drugs Resistance and Therapeutic Failure in Inflammatory Bowel Disease.
The advent of biologic drugs has revolutionized the treatment of Inflammatory Bowel Disease, increasing rates of response and mucosal healing in comparison to conventional therapies by allowing the treatment of corticosteroid-refractory cases and reducing corticosteroid-related side effects. However...
S-EPMC10931715 | biostudies-literature
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [Affymetrix]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41972 | biostudies-arrayexpress
UnknownImplementation of infection prevention and control components in Italian hospitals based on a nationwide survey on behalf of INSIEME project.
We aim to assess the state-of-the-art of Infection Prevention and Control (IPC) practices and their results in Italian healthcare facilities 6 years after the kick-off of the new National Plan for the Control of Antibiotic Resistance (PNCAR). This was a multicenter, cross-sectional, observational st...
S-EPMC12546834 | biostudies-literature
UnknownErgonomics in the operating room and surgical training: a survey on the Italian scenario.

Introduction

Surgical-related injuries are frequent, in fact the reported percentage of musculoskeletal disorders in surgeons is between 47% and 87%. These conditions are caused by long periods of standing, incorrect postures, repeated movements, little rest between operations, the lack of i...
S-EPMC11337608 | biostudies-literature
UnknownA machine-learning based bio-psycho-social model for the prediction of non-obstructive and obstructive coronary artery disease.

Background

Mechanisms of myocardial ischemia in obstructive and non-obstructive coronary artery disease (CAD), and the interplay between clinical, functional, biological and psycho-social features, are still far to be fully elucidated.

Objectives

To develop a machine-learning (ML) mod...
S-EPMC10449670 | biostudies-literature
UnknownComorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO).
Background: Italy has one of the world's oldest populations, and suffered one the highest death tolls from Coronavirus disease 2019 (COVID-19) worldwide. Older people with cardiovascular diseases (CVDs), and in particular hypertension, are at higher risk of hospitalization and death for COVID...
S-EPMC7583635 | biostudies-literature
UnknownTocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial.

Background

Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.

Methods

A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study...
S-EPMC7576974 | biostudies-literature
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