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GenomicsDynamic Changes in Ezh2 Gene Occupancy Underlie Its Involvement in Neural Stem Cell Self-Renewal and Differentiation towards Oligodendrocytes
BACKGROUND: The polycomb group protein Ezh2 is an epigenetic repressor of transcription originally found to prevent untimely differentiation of pluripotent embryonic stem cells. We previously demonstrated that Ezh2 is also expressed in multipotent neural stem cells (NSCs). We showed that Ezh2 expres...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-31655 | biostudies-arrayexpress
TranscriptomicsKC002-EH005: Genetic and epigenetic features of induced pluripotent stem cell-derived dopaminergic neurons
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro disease modeling and cell replacement therapy for Parkinson’s disease (PD). Both applications crucially require an in-depth profiling of the disease-relevant, iPSC-derived cell type. Midbrain dopaminergic (mDA) neurons derived fr...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-47178 | biostudies-arrayexpress
GenomicsDetailed analysis of the genetic and epigenetic signature of iPS cell-derived mesodiencephalic dopaminergic neurons
Induced pluripotent stem cells (iPSCs) harbor great promise for in vitro generation of disease-relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in Parkinson’s disease. Although iPSC-derived midbrain DA neurons have been generated, detailed genetic and epigenetic cha...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-55475 | biostudies-arrayexpress
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