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TranscriptomicsDysregulated expression and alternative splicing of genes controlling neuritogenesis and axon guidance revealed by exon-sensitive microarrays in models of neurodegeneration
This SuperSeries is composed of the following subset Series: GSE21298: Profiling wt SOD versus ALS SOD1(G93A) mutant GSE21305: Profiling neuroblastoma SH-SY5Y with Paraquat treatment Mitochondrial dysfunction has been directly or indirectly implicated in the pathogenesis of a number of neurodegener...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21450 | biostudies-arrayexpress
TranscriptomicsProfiling wt SOD versus ALS SOD1(G93A) mutant
Whole-genome profiling of SH-SY5Y cells was done on neuroblastoma SH-SY5Y stably transfected with cDNAs coding for SOD1WT or the mutant SOD1(G93A) protein. Five wt SOD versus five mutant SOD
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21298 | biostudies-arrayexpress
TranscriptomicsProfiling neuroblastoma SH-SY5Y with Paraquat treatment
Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared w...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21305 | biostudies-arrayexpress
TranscriptomicsApoptosis induced by Piroxicam/Cisplatin combined treatment is triggered by p21 in mesothelioma
Here we report that piroxicam/cisplatin combined treatment exerts an apoptotic effect on mesothelioma cells. Genome-wide transcriptome analyses lead us to identify p21 as the possible apoptosis mediator acting as downstream target of the piroxicam/cisplatin treatment. To analyze the potential therap...
ORGANISM(S): Homo sapiens 
2011-11-20 | E-GEOD-22445 | biostudies-arrayexpress
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