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UnknownRisk factors for bleeding in haemato-oncology patients-a nested case-control study: The BITE study protocol (Bleeding In Thrombocytopenia Explained).

Introduction

Haemato-oncological patients often receive platelet count driven prophylactic platelet transfusions to prevent bleeding. However, many prophylactically transfused patients still bleed. More knowledge on risk factors for bleeding is therefore needed. This will enable identificati...
S-EPMC7328810 | biostudies-literature
UnknownThrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia - a nested case-control study.
We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia. In this case-control study nested in a cohort of 859...
S-EPMC7782440 | biostudies-literature
UnknownExamining the Heterogeneous Genome Content of Multipartite Viruses BMV and CCMV by Native Mass Spectrometry.
Since the concept was first introduced by Brian Chait and co-workers in 1991, mass spectrometry of proteins and protein complexes under non-denaturing conditions (native MS) has strongly developed, through parallel advances in instrumentation, sample preparation, and data analysis tools. However, th...
S-EPMC4869746 | biostudies-literature
UnknownLiver-tumor mimics as a potential translational framework for planning and testing irreversible electroporation with multiple electrodes.
Irreversible electroporation (IRE) has emerged as an appealing non-ionizing, non-thermal ablation therapy, independent of antineoplastic drugs. Limited but successful outcomes in IRE conducted in vivo, in small focal hepatocellular carcinomas (HCC), have been reported. Nonetheless, the electric para...
S-EPMC10771569 | biostudies-literature
UnknownDevelopment and external validation of a nomogram to predict overall survival following stereotactic body radiotherapy for early-stage lung cancer.

Background

Prognostication tools for early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) are currently lacking. The purpose of this study was to develop and externally validate a nomogram to predict overall survival in individual patient...
S-EPMC7178957 | biostudies-literature
UnknownAugmented Reality Implementation in Minimally Invasive Surgery for Future Application in Pulmonary Surgery: A Systematic Review.

Objective

This systematic review investigates of Augmented Reality (AR) systems used in minimally invasive surgery of deformable organs, focusing on initial registration, dynamic tracking, and visualization. The objective is to acquire a comprehensive understanding of the current knowledge, ...
S-EPMC11475712 | biostudies-literature
ProteomicsIdentification of osteolineage cell-derived extracellular vesicle cargo implicated in hematopoietic support
Osteolineage cell-derived extracellular vesicles (EVs) play a regulatory role in hematopoiesis and have been shown to promote the ex vivo expansion of human hematopoietic stem and progenitor cells (HSPCs). Here, we demonstrate that EVs from different human osteolineage sources do not have the same H...
ORGANISM(S): Homo sapiens (Human) 
2020-02-28 | PXD017172 | Pride
Bone Hematopoietic expansion Hematopoietic niche Intercellular communication 
UnknownNeuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates.
Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1+
S-EPMC5318658 | biostudies-literature
UnknownOsteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells.
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including...
S-EPMC5009378 | biostudies-literature
UnknownReal-time data in cancer registries: Validation of an automated data extraction system.
Timely surveillance of cancer treatment requires real-time integration of electronic health records (EHR) data into population-based registries. We validated data from the Datagateway, an automated system that harmonizes structured EHR data across hospitals into a common model to support near real-t...
S-EPMC12303076 | biostudies-literature
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