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ProteomicsPathways to spontaneous immortalization: proteome changes underlying the transition from primary cultures to fish cell lines
Quantitative proteomics identified passage 4 (P4) as a pivot from transient surges to durable, post-crisis proliferation of two independently derived L. tenuis embryonic cell cultures (LtE-1 and LtE-2). A shift from expression of fibroblast to epithelial protein markers occurred around the crisis pi...
ORGANISM(S): Leuresthes Tenuis 
2026-06-17 | PXD070142 | panorama
ProteomicsGlobal stabilization of the mitochondrial proteome is associated with extreme anoxia tolerance in Austrofundulus limnaeus WS40NE cells
Austrofundulus limnaeus is an extremophile vertebrate native to small temporary ponds of Venezuela. Embryos of A. limnaeus must survive variable and often extreme conditions, including long periods of anoxia. Neuroepithelial cells derived from these embryos, WS40NE cells, provide a unique tool to un...
ORGANISM(S): Austrofundulus Limnaeus 
2026-08-27 | PXD074475 | panorama
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