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GenomicsChIP-Seq of HA tagged ZFP57 and KAP1 in mouse ES cells
We have performed ChIP seq analysis to obtain the positions of KAP1 and ZFP57 binding sites in mouse ES cells. By comparing the two lists, we were able to find bona fide sites. ChIP-Seq of HA tagged ZFP57 and KAP1 in mouse ES cells
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-31181 | biostudies-arrayexpress
TranscriptomicsKRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [array]
A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO cells
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-44063 | biostudies-arrayexpress
TranscriptomicsKRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [Seq]
A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO (or KD) ce...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-44061 | biostudies-arrayexpress
GenomicsZEB1 in 3T3-L1 differentiation (ChIP-seq)
We aimed to characterise genome-wide ZEB1 binding pattern in 3T3-L1 cells at distinct timepoints of adipogenic differentiation (days -2, 0, 2 and 4). We performed replicate experiments at days -2 and 0 and single experiments at days 2 and 4.
ORGANISM(S): Mus musculus 
2014-09-17 | E-MTAB-2537 | biostudies-arrayexpress
TranscriptomicsZEB1 in 3T3-L1 differentiation (RNA-seq)
We aimed to characterise genome-wide gene expression changes upon ZEB1 knockdown in 3T3-L1 cells at distinct timepoints of adipogenic differentiation (days 0 and 2), performing replicate experiments.
ORGANISM(S): Mus musculus 
2014-09-17 | E-MTAB-2538 | biostudies-arrayexpress
GenomicsTRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators c...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-41903 | biostudies-arrayexpress
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