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TranscriptomicsTranscription profiling of spinal cords from nmd mice tranplanted with ALDHhiSSClo neural stem cells to study molecular mechanism of delayed SMARD1 disease progression induced by the transplantation.
SMARD1 is an infantile autosomal recessive motor neuron (MN) disease, caused by mutations in the Immunoglobulin mu binding protein 2 (IGHMBP2). We investigated the potential of a spinal cord neural stem cell population isolated on the basis of aldehyde dehydrogenase activity (ALDH) to modify disease...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3075 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of native and disease-corrected motor neurons from human spinal muscular atrophy induced pluripotent stem cells free of vector and transgenic sequences
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27207 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPSC) obtained by reprogramming SMA patient and his healthy father fibroblasts, and gene...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27205 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by corresponding fibroblasts
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPS cells) obtained by reprogramming SMA patient and his healthy father fibroblasts, and...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27206 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse laser-microdissected motorneurons in a Spinal Muscular Atrophy model (SMA)
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-10224 | biostudies-arrayexpress
TranscriptomicsDirect reprogramming of human astrocytes into neural stem cells and neurons
Ectopic expression of the reprogramming factors OCT4, SOX2, or NANOG into human astrocytes in specific cytokine/culture conditions activated the neural stem gene program and induced generation of cells expressing neural stem/precursor markers. Here we compare the whole gene expression profile of pri...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-36145 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of spinal cord obtained from a mouse model of severe Spinal Muscular Atrophy (SMA)
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. No effective therapy is currently available. It has been suggested that M-NM-2-lactam antibiotics such as ceftriaxone may offer neuroprotection i...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-19674 | biostudies-arrayexpress
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
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