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ProteomicsIdentification of CDK8 and CDK19 substrates in human cells using cortistatin A and quantitative phosphoproteomics
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we report here the first large-scale identification of Mediator kinase substrates in human cells (HCT116). Among over 16,000 quantified sites, we identified 78 high-confidence Mediator kinase targets...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD003698 | Pride
Orbitrap velos Proteomics Mediator Quantitative Silac Orbitrap ltq Hct116 Colorectal carcinoma Cdk19 Cortistatin a Phosphoproteomics Cdk8 
Transcriptomics24hr CA treatment vs. DMSO in HCT116 cells (from 'Identification of CDK8 and CDK19 substrates in human cells using cortistatin A and quantitative phosphoproteomics')
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we report here the first large-scale identification of Mediator kinase substrates in human cells (HCT116). Among over 16,000 quantified phosphosites, we identified 78 high-confidence Mediator kinase...
ORGANISM(S): Homo sapiens 
2016-02-26 | E-GEOD-78506 | biostudies-arrayexpress
GenomicsCortistatin A treatment effects on umbilical cord blood-derived megakaryocytes
Cortistatin A treatment effects on umbilical cord blood-derived megakaryocytes
PRJNA1102295 | ENA
GenomicsEffects of Cortistatin A on cord blood-derived megakaryocytes at 96 h
Effects of Cortistatin A on cord blood-derived megakaryocytes at 96 h
PRJNA1102301 | ENA
GenomicsLack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia
Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia
PRJNA1290217 | ENA
UnknownSynthesis of (+)-cortistatin A.
Not available
S-EPMC2652360 | biostudies-literature
GenomicsCortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
PRJNA855254 | ENA
UnknownFormal total synthesis of (±)-cortistatin A.
Not available
S-EPMC2909620 | biostudies-literature
UnknownDidehydro-Cortistatin A: a new player in HIV-therapy?
Not available
S-EPMC4793404 | biostudies-literature
TranscriptomicsCortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
Background: Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood-brain barrier (BBB). Brain endothelium dysfunction is a hallmark of BBB breakdown in most neurodegenerative/neuroinflammatory disorders. Therefore, the ident...
ORGANISM(S): Mus musculus 
2023-09-01 | GSE207405 | GEO
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