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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsAcute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder
The aim of the study was to investigate the involvement of the mTOR pathway in the autism spectrum disorder. Adolescent male rats, prenatally exposed to valproic acid (500 mg/kg ip on gestational day 12.5), were treated with the mTOR inhibitor rapamycin (10 mg/kg, ip, two consecutive days starting a...
ORGANISM(S): Rattus norvegicus 
2022-09-06 | E-MTAB-12056 | biostudies-arrayexpress
UnknownToxoplasma-induced changes in host risk behaviour are independent of parasite-derived AaaH2 tyrosine hydroxylase.
Not available
S-EPMC5653819 | biostudies-literature
UnknownUse of glucocorticoids megadoses in SARS-CoV-2 infection in a spanish registry: SEMI-COVID-19.
Not available
S-EPMC8782507 | biostudies-literature
UnknownEmbryonic Thermal Manipulation Affects Ventilation, Metabolism, Thermal Control and Central Dopamine in Newly Hatched and Juvenile Chicks.
Not available
S-EPMC8249324 | biostudies-literature
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (testing dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-19616 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (training dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-11990 | biostudies-arrayexpress
UnknownThe biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis.
Not available
S-EPMC11217049 | biostudies-literature
TranscriptomicsFunctional characterization of a Drosophila melanogaster mitochondrial deoxynucleotide transporter dRIM2.
We have studied the deoxynucleotide transport in Drosophila melanogaster. On the basis of homology with the S. cerevisiae RIM2 gene, encoding a pyrimidine deoxynucleotide carrier (Marrobbio et al. 2006), the CG18317 gene (dRIM2) in the fruit fly may code for a deoxynucleotide carrier. We demonstrate...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-48012 | biostudies-arrayexpress
UnknownDevelopment and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study.
Not available
S-EPMC9129872 | biostudies-literature
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