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MetabolomicsDissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...
2019-06-07 | MTBLS677 | MetaboLights
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
GenomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (MBD-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59960 | biostudies-arrayexpress
GenomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59979 | biostudies-arrayexpress
UnknownEffects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study.
Not available
S-EPMC6453765 | biostudies-literature
UnknownRare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.
Not available
S-EPMC12633141 | biostudies-literature
UnknownPsychiatric genetics in the diverse landscape of Latin American populations.
Not available
S-EPMC12133068 | biostudies-literature
UnknownGenome-wide association study of obsessive-compulsive disorder.
Not available
S-EPMC4218751 | biostudies-literature
UnknownEvidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Not available
S-EPMC5114162 | biostudies-literature
UnknownPartitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.
Not available
S-EPMC3812053 | biostudies-literature
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