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MetabolomicsDissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...
2019-06-07 | MTBLS677 | MetaboLights
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
MetabolomicsDiversity in DNA: Identification of methylated deoxyadenosines in higher eukaryotes
Since the discovery that cytosine deoxynucleotides could be methylated (dC5m), not much is known in higher eukaryotes about modifications affecting other deoxynucleotides. Here, we now report that we detected N-6-methyl-deoxyadenosine (dA6m) not only in frog DNA, but also in other species including ...
2015-11-16 | MTBLS276 | MetaboLights
ProteomicsProteomic analysis of murine small intestinal epithelial cells pre-and postweaning
Characterization of the global, organ-and site-specific as well as single-cell transcriptional and proteomic profile of the small intestinal epithelium at different time points after birth. The proteomic analysis was performed on total isolated small intestinal epithelium from 1-,5-,1-0 and 25-day-o...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-23 | PXD059639 | Pride
Small intestinal epithelium Lfq-based proteomics Postnatal maturation 
MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
UnknownImportant underground roosts for bats in Bulgaria: current state and priorities for conservation.
Not available
S-EPMC10848659 | biostudies-literature
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
UnknownCytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project.
Not available
S-EPMC10616076 | biostudies-literature
Unknown"Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study".
Not available
S-EPMC7456194 | biostudies-literature
UnknownCalcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study.
Not available
S-EPMC8224356 | biostudies-literature
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