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TranscriptomicsThe RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation.
Deletion of the flap loop in the Rp2 subunit of human RNAPII did not alter the ability of human RNAPII to initiate transcription or elongate the initiated transcripts in vivo and in vitro, and was also dispensable for elongation factor-mediated enhancement and inhibition of transcript elongation in ...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-29734 | biostudies-arrayexpress
UnknownOvercoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.
Not available
S-EPMC538767 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of human cell lines with oestrogen receptor (ER), the E2F transcription factor 4 (E2F4),
The Goal of the experiment was to validate the predicted regulatory modules identified by an algorithm.For this we took advantage of the the genome-wide location analysis technique (or ?ChIP/chip?). We selected modules predicted to be bound by the estrogen receptor (ER), the E2F transcription factor...
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-471 | biostudies-arrayexpress
TranscriptomicsMRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts
Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare the...
ORGANISM(S): Saccharomyces cerevisiae 
2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress
UnknownKeratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer.
Not available
S-EPMC10433649 | biostudies-literature
UnknownKRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment.
Not available
S-EPMC11024060 | biostudies-literature
UnknownIdentification of carbon dioxide in an exoplanet atmosphere.
Not available
S-EPMC9946830 | biostudies-literature
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