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ProteomicsSize matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients
Glioblastoma is a fatal and devastating primary brain tumour that poses significant challenges to accurate tumour monitoring and patient treatment. Substantial efforts are underway to develop accurate non-invasive liquid biopsy methods that can routinely assess glioblastoma markers in patient body f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051553 | Pride
Gliioblastoma Extracellular vesicles Liquid biopsy Urine 
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in the Lungs of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer
COPD is a common and disabling lung disease for which very few therapeutic options are currently available. We reasoned that global gene expression profiling of COPD lungs could reveal previously unidentified disease pathways for potential therapeutic interventions. Forty-eight human lung samples we...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8500 | biostudies-arrayexpress
GenomicsA hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition [Pol2ChIP]
ChIP-seq of total Pol II in G1E ER4 cell line at time points after mitosis. Nocodazole arrest-release in G1E ER4 cell line under conditions of 13h estradiol treatment.
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-83263 | biostudies-arrayexpress
GenomicsA hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition [Hist]
ChIP-seq of H3K27Ac in the G1E-ER4 cell line in prometaphase (nocodazole block), between anaphase-telophase (nocodazole release 40min), and interphase (asynchronous). Nocodazole arrest-release in G1E ER4 cell line under conditions of 13h estradiol treatment.
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-83255 | biostudies-arrayexpress
TranscriptomicsFunctional genomic analysis of the periodic transcriptome in the developing Drosophila wing.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2014-03-15 | E-GEOD-54928 | biostudies-arrayexpress
TranscriptomicsFunctional genomic analysis of the periodic transcriptome in the developing Drosophila wing [Affymetrix]
The eukaryotic cell cycle, driven by both transcriptional and post-translational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. While genome-wide studies have investigated cell cycle-associated transcription in unicellular systems, global patterns of pe...
ORGANISM(S): Drosophila melanogaster 
2014-03-15 | E-GEOD-54926 | biostudies-arrayexpress
TranscriptomicsLimbal Niche
Comprehensive transcriptome analysis of four distinct human limbal compartments, including basal limbal crypts (BLCs), superficial limbal crypts (SLCs), cornea, and the supporting stroma, with the aid of laser capture microdissection and deep RNA sequencing.
ORGANISM(S): Homo sapiens 
2013-07-01 | E-MTAB-1498 | biostudies-arrayexpress
GenomicsPost-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation (ChIP-seq)
SAGA is a highly conserved transcriptional co-activator complex involved in multiple steps of transcription with activities that function both pre and post initiation. Loss of individual subunits results in developmental defects, suggesting a role in development. To better understand the roles of SA...
ORGANISM(S): Drosophila melanogaster 
2011-08-22 | E-GEOD-29513 | biostudies-arrayexpress
TranscriptomicsIntegrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression
Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilisation in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here we report the first transcr...
ORGANISM(S): Plasmodium falciparum 
2016-06-28 | E-GEOD-75795 | biostudies-arrayexpress
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