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TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from HIV patients vs uninfected controls suggest that monocyte function is diminished during high-level HIV viremia and that this effect is mediated by chronic stimulation by type I interferons
The effect of human immunodeficiency virus (HIV) infection and high-level HIV replication on the function of monocytes was investigated. HIV-positive patients had elevated levels of spontaneous production of some or all of the monocyte proinflammatory cytokines measured (interleukin-1beta [IL-1beta]...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5220 | biostudies-arrayexpress
TranscriptomicsFunctionally conserved non-coding regulators of cardiomyocyte proliferation and regeneration in mouse and human
The adult mammalian heart has little regenerative capacity after myocardial infarction (MI) while neonatal mouse heart regenerates without scarring or dysfunction. However, the underlying pathways are poorly defined. We sought to derive insights into the pathways regulating neonatal development of t...
ORGANISM(S): Mus musculus 
2018-02-02 | E-MTAB-6272 | biostudies-arrayexpress
TranscriptomicsModelling Skeletal Muscle Ageing and Repair In Vitro
Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. Understanding which signalling pathways are associated with re...
ORGANISM(S): Homo sapiens 
2023-07-05 | E-MTAB-12248 | biostudies-arrayexpress
GenomicsActivation of the Integrated Stress Response by a Jumonji Histone Demethylase Inhibitor Induces Pro-Apoptotic Metabolic Reprogramming in Multiple Myeloma
Regulation of gene expression by chromatin modification through methylation of histone lysine residues is a dynamic, reversible process that when deregulated is associated with cancer development. In multiple myeloma, combined inhibition of the histone demethylases JARID1B, UTX and JmjD3 by the smal...
ORGANISM(S): Homo sapiens 
2015-08-21 | E-GEOD-60626 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput of Blumeria gramis during infection of Barley
The aim of this experiment was to investigate the transcriptomic variation within Blumeria graminis f. sp. hordei during infection of Barley. SOLiD RNA-seq data was generated for 6 samples, three from the epiphytic hyphae and three from the haustoria within the epidermis.
ORGANISM(S): Blumeria graminis 
2012-06-11 | E-MTAB-682 | biostudies-arrayexpress
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