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ProteomicsEvaluation of iTRAQ and SWATH-MS for the quantification of proteins associated with insulin resistance in human duodenal biopsy samples
Insulin resistance (IR) is associated with increased production of triglyceride-rich lipoproteins of intestinal origin. In order to assess whether insulin resistance affects the proteins involved in lipid metabolism, we used two mass spectrometry based quantitative proteomics techniques to compare t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080194 | MassIVE
TranscriptomicsGene expression profile of normal and calcified stenotic human aortic valves
We explored gene expression profile of human aortic valves in patients with or without aortic stenosis. The dataset that we generated constitutes a large-scale quantitative measurements of gene expression in normal and stenotic human valves. The goal was to compare gene expression levels between the...
ORGANISM(S): Homo sapiens 
2009-07-09 | E-GEOD-12644 | biostudies-arrayexpress
TranscriptomicsThe tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing
Corneal injuries remain a major cause of consultation in the ophthalmology clinics worldwide. Repair of corneal wounds is a complex mechanism that involves cell death, migration, proliferation, differentiation, and extracellular matrix (ECM) remodeling. In the present study, we used a tissue-enginee...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75336 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of E157D PPARγ transcriptional activity in NIH-3T3 fibroblasts
The E157D PPARγ mutation presents as an atypical case of familial partial lipodystrophy and diabetes in a human cohort and has a novel molecular mechanism. The mutation is located in the DNA-binding domain, has no dominant negative activity but disrupts transcription activation after the protein ha...
ORGANISM(S): Mus musculus 
2012-05-15 | E-GEOD-37990 | biostudies-arrayexpress
TranscriptomicsGene transcription profiling in wild and laboratory-exposed eels reveals common responses to low temperature and chronic pollution exposure
Aquatic ecosystems are subjected to a variety of man-induced stressors but also vary spatially and temporally due to variation in natural factors. In such complex environments, it remains difficult for ecotoxicologists to evaluate the effects of contaminants in wild organisms. The aim of the present...
ORGANISM(S): Anguilla anguilla 
2015-01-01 | E-GEOD-64170 | biostudies-arrayexpress
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