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Identification of covalent small-molecule inhibitors of STING
Immunological proteins are major disease targets, and the majority remain undrugged. Post-translational redox modification of protein cysteine residues has emerged as a mode of immune cell regulation, especially in the context of the macrophage cytokine response. Here, we develop a strategy for syst...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-17 | PXD072062 | Pride
Peroxisome proliferator-activated receptor gamma (PPARγ) is a validated therapeutic target for type 2 diabetes (T2D), but current FDA-approved agonists such as the glitazones are limited by adverse effects. SR10171, a non-covalent partial inverse agonist with modest binding potency, improves insulin...
ORGANISM(S): Homo sapiens (Human) 
2025-11-15 | PXD066095 | Pride
Genome-wide occupancy of PPARG and RXRA after treatment with PPARG inverse agonist
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