Sort   by:  
 Page size 
ProteomicsOpen-source electrophilic fragment screening platform for UCHL1 covalent inhibitors
Data in support of the manuscript "Open-source electrophilic fragment screening platform for UCHL1 covalent inhibitors"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-06 | MSV000096608 | MassIVE
ProteomicsCovalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
As the global fight against antimicrobial resistance in bacteria becomes increasingly pressing, new tool compounds are needed to understand and identify novel therapeutic targets. Here, cysteine-directed fragment-based drug discovery is coupled with a high throughput chemistry direct-to-biology scre...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD057304 | Pride
Bacterial nels Fragment-based drug discovery Covalent fragments Salmonella effectors Chemoproteomics E3 ligase High throughput chemistry 
UnknownQuantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening.
Not available
S-EPMC7842680 | biostudies-literature
UnknownRapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
Not available
S-EPMC6556873 | biostudies-literature
GenomicsTarget discovery by covalent phenotypic screening in a stem cell differentiation model
Target discovery by covalent phenotypic screening in a stem cell differentiation model
PRJNA1399351 | ENA
UnknownIdentification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Not available
S-EPMC11494320 | biostudies-literature
UnknownCovalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation.
Not available
S-EPMC9070689 | biostudies-literature
UnknownFragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
Not available
S-EPMC6383986 | biostudies-literature
ProteomicsEnantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation
Here we present a chemoproteomics fragment screening platform for identifying novel DUB-specific hit matter, that combines activity-based protein profiling with high-throughput chemistry direct-to-biology optimisation to enable rapid elaboration of initial fragment hits against OTU DUBs. Applying th...
ORGANISM(S): Homo sapiens (Human) 
2025-01-13 | PXD054883 | Pride
Chemoproteomics Covalent fragments Data-independent acquisition Activity-based protein profiling Deubiquitinating enzymes 
TranscriptomicsTarget discovery by covalent phenotypic screening in a stem cell differentiation model
We performed a high throughput screen of a newly curated covalent fragment library comprising 894 compounds. The phenotypic screen was designed to identify signalling pathway modulators and constituted a differentiation assay whereby primed human induced pluripotent cells (iPSCs) were differentiated...
ORGANISM(S): Homo sapiens 
2026-09-28 | GSE315812 | GEO
Sort   by:  
 Page size