Covalent fragments

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Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments.

Not available

S-EPMC6319256 | biostudies-literature

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization.

Not available

S-EPMC8155467 | biostudies-literature

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.

Not available

S-EPMC8201753 | biostudies-literature

Targeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (ChIP-Seq)

Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...

ORGANISM(S): Homo sapiens

2013-12-23 | E-GEOD-50622 | biostudies-arrayexpress

Integrated Phenotypic and Activity-Based Profiling of Electrophilic Fragments Reveals New Targets for Antibiotics Development

The emergence of antibiotic resistance necessitates the discovery of novel bacterial targets and antimicrobial agents. Here, we present a bacterial target discovery framework that integrates phenotypic screening of cysteine-reactive fragments with competitive activity-based protein profiling to map ...

ORGANISM(S): Shigella flexneri S5644 Bacteria

2025-05-07 | PXD058002 | Pride