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TranscriptomicsIL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals.
HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we investigated the global gene expression profile of circulating CD4+ T cells from distinct clinical status of HTLV-1-infected individuals in regard to Tax expression levels. CD4+ T ce...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-38537 | biostudies-arrayexpress
TranscriptomicsMesenchymal Stem Cells Promote the Sustained Expression of CD69 on Activated T-lymphocytes: Roles of Canonical and Non-Canonical NF-κB Signaling
Mesenchymal stem cells (MSCs) are known to induce the conversion of activated T-cells into regulatory T-cells in vitro. The marker CD69 is a target of canonical NF-κB signaling and is transiently expressed upon activation; however, stable CD69 expression defines cells with immunoregulatory propertie...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-31153 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of T cell subsets from MS patients undergoing autologous hematopoietic stem cell transplantation reveals significant changes in immune function
Multiple sclerosis is an immune mediated disease of the central nervous system. High-dose immunosuppression therapy followed by autologous hematopoietic stem cell transplantation (HDI/AHSCT) has emerged in the past few years as a new treatment strategy in patients with severe MS and refractory to co...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-32988 | biostudies-arrayexpress
TranscriptomicsPotential Roles of miR-29a in the Molecular Pathophysiology of T-Cell Acute Lymphoblastic Leukemia
The miR-29 family is an important player in the molecular pathophysiology of distinct types of cancer, with roles that seems to depend on cellular context. Reduced miR-29 levels are associated with more aggressive disease and its overexpression in cancer and leukemic cell lines inhibits proliferatio...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48063 | biostudies-arrayexpress
TranscriptomicsCultured human adipose tissue pericytes and mesenchymal stromal cells display a very similar gene expression profile
Mesenchymal stromal cells (MSCs) are cultured cells that can give rise to mature mesenchymal cells under appropriate conditions, and secrete a number of biologically relevant molecules that may play an important role in regenerative medicine. Evidence indicates that pericytes (PCs) correspond to mes...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-67747 | biostudies-arrayexpress
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