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TranscriptomicsGenomic analysis of hESC pedigrees enables identification of de novo genetic alterations and determination of the timing and origin of mutational events
Given the association between mutational load and cancer, the observation that genetic aberrations are frequently found in human pluripotent stem cells (hPSCs) is of concern. Prior studies in hiPSCs have shown that deletions and regions of loss-of-heterozygosity (LOH) tend to arise during reprogramm...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49452 | biostudies-arrayexpress
UnknownPerioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial.
Not available
S-EPMC5559335 | biostudies-literature
TranscriptomicsSingle epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration
By contrast with mammals, adult zebrafish have a high capacity to regenerate damaged or lost myocardium through proliferation of spared cardiomyocytes. The epicardial sheet covering the heart is activated by injury and aids muscle regeneration through paracrine effects and as a multipotent cell sou...
ORGANISM(S): Danio rerio 
2015-12-15 | E-GEOD-75583 | biostudies-arrayexpress
UnknownMaternal Hepatitis B Virus or Hepatitis C Virus Carrier Status and Long-Term Endocrine Morbidity of the Offspring-A Population-Based Cohort Study.
Not available
S-EPMC7141343 | biostudies-literature
ProteomicsThe mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1
Acquiring new cellular states entails metabolic reprogramming driven by adjustments to the expression of metabolic enzymes in the cytosol and mitochondria. Most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondria in a linear form, after which they are folded by a...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD066753 | Pride
Metabolism One carbon Mthfd2 Hspd1 Protein folding Hspe1 
UnknownMicrobial Interactions in the Cystic Fibrosis Airway.
Not available
S-EPMC6062800 | biostudies-literature
UnknownHybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: a target trial emulation.
Not available
S-EPMC10101759 | biostudies-literature
TranscriptomicsIrp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading
Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic associa...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-57073 | biostudies-arrayexpress
ProteomicsMultilayered Regulation of Autophagy by the Atg1 Kinase Orchestrates Spatial and Temporal Control of Autophagosome Formation
Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by utilizing de novo double membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar/lysosomal degradation. The Atg1 kinase is one of its...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-10-11 | PXD029047 | Pride
Metabolism Protein phosphatases Protein kinases Signalling Phosphorylation Ubiquitin-like proteins Autophagy Atg8 lipidation 
UnknownThe Association Between Psoriasis, Psoriatic Arthritis, and Fibromyalgia Syndrome: Effects on Treatment-A Population-Based Study.
Not available
S-EPMC12566094 | biostudies-literature
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