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MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to delinate Cysteinyl leukotrienes mode of action
Cysteinyl leukotrienes (cysLT), i.e. LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway. The cysLT receptors cysLT1-R and cysLT2-R are expressed on different target cells and mediate inflammatory reactions in tissue- and LT-R-specific ways. Though endothelial cells (EC...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3589 | biostudies-arrayexpress
ProteomicsPhosphorylation mediates hormonal, epigenetic and stress responses related to sugarcane somatic embryogenesis competence
In somatic embryogenesis, embryos are formed from a single or small group of somatic cells in response to stress and hormonal stimuli. In this study, a high-throughput phosphoproteomic analysis was used to identify and quantify phosphoproteins related to the acquisition of embryogenic competence in ...
ORGANISM(S): Saccharum hybrid cultivar SP80-3280 
2020-10-02 | PXD018054 | Pride
Abscisic acid Snrk1 Phosphoproteomics Histone deacetylase Totipotency 
UnknownAPOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
Not available
S-EPMC6328941 | biostudies-literature
TranscriptomicsTranscription profiling of human papillary serous ovarian adenocarcinomas and HUVEC and OVCA429 cells lines treated with recombinant MAGP2 - SuperSeries
This SuperSeries is composed of the following subset Series:; GSE18373: Expression data of HUVEC and OVCA429 with recombinant MAGP2; GSE18520: Whole-genome oligonucleotide expression analysis of papillary serous ovarian adenocarcinomas Experiment Overall Design: Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-10-23 | E-GEOD-18521 | biostudies-arrayexpress
ProteomicsMaxDIA enables highly sensitive and accurate library-based and library-free data-independent acquisition proteomics (DDA data)
MaxDIA is a universal platform for analyzing data-independent acquisition proteomics data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves cutting-edge proteome coverage with significantly better coefficients of variation in protein quantification than other softwa...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-07-09 | PXD022582 | Pride
Maxquant Benchmark 
ProteomicsMaxDIA enables highly sensitive and accurate library-based and library-free data-independent acquisition proteomics (DIA data)
MaxDIA is a universal platform for analyzing data-independent acquisition proteomics data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves cutting-edge proteome coverage with significantly better coefficients of variation in protein quantification than other softwa...
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) Escherichia coli 
2021-07-09 | PXD022589 | Pride
Maxquant Benchmark 
UnknownCommunicating the relative health risks of E-cigarettes: An online experimental study exploring the effects of a comparative health message versus the EU nicotine addiction warnings on smokers' and non-smokers' risk perceptions and behavioural intentions.
Not available
S-EPMC6891257 | biostudies-literature
UnknownProtective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.
Not available
S-EPMC5920701 | biostudies-literature
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