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TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
TranscriptomicsCOX-2 network as predictive molecular marker for clinical pregnancy in IVF
CONTEXT Nowadays, the molecular mechanisms involved in endometrial receptivity and implantation are still not clear. OBJECTIVE The gene expression of human endometrium of patients undergoing an IVF treatment with GnRH antagonists/rec-FSH was studied. CONCLUSIONS COX-2 has been extensively studied ...
ORGANISM(S): Homo sapiens 
2010-09-06 | E-GEOD-18140 | biostudies-arrayexpress
GenomicsMyeloid Cell COX-2 Deficiency Exacerbated Salt-Sensitive Hypertension
Myeloid Cell COX-2 Deficiency Exacerbated Salt-Sensitive Hypertension
PRJNA1531611 | ENA
ProteomicsActivity-dependent COX-2 proteolysis
Cyclooxygenase-2 (COX-2) catalyzes the oxidation of arachidonic acid (AA) into a single product that is the source of all prostaglandins (PGs), ligands of multiple pro-inflammatory pathways. AA catalysis results in suicide inactivation, rendering the enzyme catalytically inactive. We report that cat...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-25 | PXD057448 | Pride
Proteolysis Cyclooxygenase-2 Arachidonic acid 
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
TranscriptomicsCell Intrinsic role of Cox-2 in pancreatic cancer development
Cyclooxygenase-2 (COX-2) is upregulated in pancreatic ductal adenocarcinomas (PDAC). However, how COX-2 promotes PDAC development is unclear. While previous studies have evaluated the efficacy of COX-2 inhibition via the use of non steroidal anti-inflammatory drugs (NSAIDs) or the COX-2 inhibitor ce...
ORGANISM(S): Mus musculus 
2012-06-28 | E-GEOD-38988 | biostudies-arrayexpress
TranscriptomicsCOX-2 overexpression in a conditional KrasG12D mouse model
Pancreatic ductal cells and preneoplastic lesions derived from wild type, Keratin 5 COX-2, P48Cretg/wt K-RasG12D/wt and K5 COX-2 P48Cretg/wt K-RasG12D/wt mouse genotypes were laser capture microdissected. Total RNA was isolated and analysed with Illumuna Sentrix 8 chips.
ORGANISM(S): Mus musculus 
2019-06-24 | E-MTAB-2688 | biostudies-arrayexpress
GenomicsMyeloid Cell COX-2 Deficiency Exacerbated Salt-Sensitive Hypertension [RNA-Seq]
Myeloid Cell COX-2 Deficiency Exacerbated Salt-Sensitive Hypertension [RNA-Seq]
PRJNA1531632 | ENA
GenomicsEndothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases
Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases
PRJNA966093 | ENA
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
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