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TranscriptomicsRNA-seq of medulloblastoma spheroid models
Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblastoma able to recapitulate the spatial conformation, cell-cell and cellmatri...
ORGANISM(S): Homo sapiens 
2021-03-06 | E-MTAB-10127 | biostudies-arrayexpress
TranscriptomicsRNAseq of 6 medulloblastoma cell lines
Medulloblastoma is subdivided into different subgroups: WNt, SHH, Group 3 and Group 4. Since these subgroups are associated with different OS and metastasis rates it is crucial to understand them better. Six medulloblastoma cell lines, DAOY, ONS-76, D458, HD-MB03, CHLA-01-MED, CHLA-01R-MED, have bee...
ORGANISM(S): Homo sapiens 
2022-03-02 | E-MTAB-9823 | biostudies-arrayexpress
TranscriptomicsscRNAseq of two medulloblastoma cell lines (ONS-76 and HDMB-03) grown in 3D hydrogel culture
Two medulloblastoma cell lines (ONS-76 and HDMB-03) were grown in 3D hyaluronan hydrogels for three weeks. We observed nodules forming showing different behavior and wanted to evaluate if these different nodules (slow vs fast vs non-growing, migrating and invading cells) are also characterised by di...
ORGANISM(S): Homo sapiens 
2023-02-23 | E-MTAB-12591 | biostudies-arrayexpress
UnknownStructural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Not available
S-EPMC125701 | biostudies-literature
TranscriptomicsGene expression analysis of primitive neuroectodermal tumors
Central nervous system primitive neuroectodermal tumors (CNS PNET) and medulloblastomas are both embryonal tumors that predominantly occur in children. We used microarrays to analyse a cohort of CNS PNETs and medulloblastomas to identify gene expression related to tumor subgroups. RNA extracted from...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-19404 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular genetic profiling of pediatric-high grade gliomas reveals key differences with adult disease
Purpose: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). Patients and Methods: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGG, including 7 diffuse intrinsic pontine gliomas, and 10 HGG cases ar...
ORGANISM(S): Homo sapiens 
2010-06-15 | E-GEOD-19578 | biostudies-arrayexpress
UnknownProbing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.
Not available
S-EPMC5465887 | biostudies-literature
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