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TranscriptomicsCharacterization of A Novel CRAC Inhibitor that Potently Blocks Human T cell Activation and Effector Functions
Store operated calcium entry (SOCE) downstream of T cell receptor (TCR) activation in T lymphocytes has been shown to be mediated mainly through the Calcium Release Activated Calcium (CRAC) channel. Here, we compared the effects of a novel, potent and selective CRAC inhibitor, 2,6-Difluoro-N-{5-[4-m...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43210 | biostudies-arrayexpress
GenomicsCRAC channel-mediated gene expression in Treg cells
CRAC channel-mediated gene expression in Treg cells
PRJNA517500 | ENA
GenomicsCRAC channel controls the differentiation of pathogenic B cells in lupus nephritis
CRAC channel controls the differentiation of pathogenic B cells in lupus nephritis
PRJNA732374 | ENA
TranscriptomicsCRAC channel controls the differentiation of pathogenic B cells in lupus nephritis
Systemic lupus erythematous (SLE) is a prototype of autoimmune disease. Lupus nephritis (LN) is one of the most serious complications of SLE. The development of autoreactive B cells and the production of autoantibodies have been critical for the initiation and progression of LN. Store-operated Ca2+ ...
ORGANISM(S): Homo sapiens 
2021-09-01 | GSE175424 | GEO
TranscriptomicsCRAC channel-mediated gene expression in Treg cells
T regulatory (Treg) cells maintain immunological tolerance and their depletion in humans and mice results in autoimmune disease. The development of Treg cells in the thymus, their differentiation into effector T cells and their activation depends on Ca2+ release-activated Ca2+ (CRAC) channels formed...
ORGANISM(S): Mus musculus 
2019-01-29 | GSE125784 | GEO
UnknownStructural and functional mechanisms of CRAC channel regulation.
Not available
S-EPMC4459506 | biostudies-literature
UnknownRoles of CRAC channel in cancer: implications for therapeutic development.
Not available
S-EPMC7959113 | biostudies-literature
UnknownCritical parameters maintaining authentic CRAC channel hallmarks.
Not available
S-EPMC6647248 | biostudies-literature
UnknownGated regulation of CRAC channel ion selectivity by STIM1.
Not available
S-EPMC3276717 | biostudies-literature
UnknownThe STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel.
Not available
S-EPMC5764705 | biostudies-literature
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