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ProteomicsCRAF dimerization with ARAF regulates KRAS driven tumors
KRAS, mutated in ~30% of all cancers, activates the RAF-MEK-ERK signaling cascade. It has previously been shown that CRAF is required for growth of KRAS mutant lung tumors but the requirement for CRAF kinase activity is unknown. Here, we show that subsets of KRAS mutant tumors are dependent on CRA...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-29 | MSV000088285 | MassIVE
TranscriptomicsTranscription profiling of Mia PaCa-2 cancer cells treated with a cell-permeable RAS inhibitor and its negative control
The action mechanism of a cell-permeable RAS inhibitor (Pen-cRaf-v1) and its binding-disrupting mutant (Pen-cRaf-v1-AA) was studied by transcription profiling of Mia PaCa-2 cancer cells treated with the inhibitors at the concentration of 10 microM for 3 hours.
ORGANISM(S): Homo sapiens 
2021-06-01 | E-MTAB-10403 | biostudies-arrayexpress
UnknownSelective CRAF Inhibition Elicits Transactivation.
Not available
S-EPMC8041278 | biostudies-literature
UnknownCRAF R391W is a melanoma driver oncogene.
Not available
S-EPMC4897636 | biostudies-literature
UnknownBRAF inactivation drives aneuploidy by deregulating CRAF.
Not available
S-EPMC2975377 | biostudies-literature
UnknownKinase-independent role for CRAF-driving tumour radioresistance via CHK2.
Not available
S-EPMC4559870 | biostudies-literature
UnknownTargeting CRAF kinase in anti-cancer therapy: progress and opportunities.
Not available
S-EPMC10726672 | biostudies-literature
UnknownImpaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.
Not available
S-EPMC5873938 | biostudies-literature
UnknownCharacterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases.
Not available
S-EPMC12630025 | biostudies-literature
UnknownCharacterization and inhibitor sensitivity of ARAF, BRAF, and CRAF complexes.
Not available
S-EPMC12363950 | biostudies-literature
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