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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownIncorporating Digital Tools to Improve Clinical Trial Infrastructure: A White Paper From the Digital Engagement Committee of SWOG.
Not available
S-EPMC6668704 | biostudies-literature
TranscriptomicsNASH
Non-alcoholic fatty liver disease (NAFLD) is characterized by a series of pathological changes that can progress from simple fatty liver disease to non-alcoholic steatohepatitis (NASH). The objective of this study is to describe changes in global gene expression associated with the progression of NA...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-MEXP-3291 | biostudies-arrayexpress
UnknownInstitutional clinical trial accrual volume and survival of patients with head and neck cancer.
Not available
S-EPMC4279235 | biostudies-literature
TranscriptomicsDifferential expression of sorted Alpha and Beta cells
The goal of this experiment is to identify genes differentially expressed in FACS-sorted Alpha and Beta cells.
ORGANISM(S): Homo sapiens 
2011-07-23 | E-MTAB-465 | biostudies-arrayexpress
TranscriptomicsDifferential expression of representative sorted pancreatic cells
The goal of this experiment is to identify genes differentially expressed in representative pancreatic FACS-sorted cell types.
ORGANISM(S): Homo sapiens 
2011-07-26 | E-MTAB-463 | biostudies-arrayexpress
ModelsStokes2020 - Antibiotics discovery using deep learning approach.
Based on a simple E.coli growth inhibition assay, the authors trained a model capable of identifying antibiotic potential in compounds structurally divergent from conventional antibiotic drugs. One of the predicted active molecules, Halicin (SU3327), was experimentally validated in vitro and in vivo...
2024-04-22 | MODEL2404080001 | BioModels
Machine Learning Model Ersilia 
ModelsStokes2020 - Antibiotics discovery using deep learning approach (Antiviral implementation)
This model was developed to support the early efforts in the identification of novel drugs against SARS-CoV2. It predicts the probability that a small molecule inhibits SARS-3CLpro-mediated peptide cleavage. It was developed using a high-throughput screening against the 3CL protease of SARS-CoV1, as...
2024-05-08 | MODEL2405080006 | BioModels
Machine Learning Model Ersilia 
UnknownUS Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose-Positron Emission Tomography Imaging: Southwest Oncology Group S0816.
Not available
S-EPMC4966513 | biostudies-literature
ProteomicsBeta-cell Galphas signaling is critical for physiological and pharmacological enhancement of insulin secretion
Islet lysates were adjusted to 5 percent SDS in TEAB, pH 8.5, reduced and alkylated and digested with modified trypsin (Worthington) using an S-trap mini device (Protifi). Peptides were labeled with TMT16 reagents (lot ZH350094). Phosphopeptide enrichment used GL Sciences p10 TiO tips. LC-MS/MS used...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-05-13 | MSV000097882 | MassIVE
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