Sort   by:  
 Page size 
ProteomicsRedesigned peptide-based LDH5 inhibitors enter cancer cells efficiently and impair proliferation
Lactate dehydrogenase 5 (LDH5), an enzyme overexpressed in many cancers, is an attractive target for anticancer therapy. Recently, we successfully designed an LDH5 peptide inhibitor, cGmC9, by targeting protein-protein interactions required for LDH5 enzymatic activity. LDH5 is expressed in the cytos...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-06 | PXD029126 | Pride
Peptide inhibitors Lactate dehydrogenase 
UnknownDistribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.
Not available
S-EPMC4621522 | biostudies-literature
TranscriptomicsGlobal gene expression changes in patient-derived CML cell line K562 after short- and long-term BCR-ABL kinase inhibition.
K562 cells were treated with the BCR-ABL kinase inhibitor dasatinib over an extended period of time to determine how BCR-ABL inhibition affects BCR-ABL-dependent negative feedback and erythropoietin receptor (EPO-R) signaling. Specifically, what types of changes (upregulation versus downregulation)...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-51083 | biostudies-arrayexpress
UnknownMEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction.
Not available
S-EPMC4248023 | biostudies-literature
UnknownEffect of Multicomponent Home-Based Training on Gait and Muscle Strength in Older Adults After Hip Fracture Surgery: A Single Site Randomized Trial.
Not available
S-EPMC10039715 | biostudies-literature
UnknownPeptide-based LDH5 inhibitors enter cancer cells and impair proliferation.
Not available
S-EPMC11802983 | biostudies-literature
UnknownBroad-spectrum allosteric inhibition of herpesvirus proteases.
Not available
S-EPMC4108181 | biostudies-literature
UnknownBlockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations.
Not available
S-EPMC3048385 | biostudies-literature
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
UnknownDevelopment of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples.
Not available
S-EPMC10510397 | biostudies-literature
Sort   by:  
 Page size