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TranscriptomicsSingle cell RNA-seq of hiPSC-derived kidney organoids differentiated within self-assembling peptide hydrogels and the animal-derived matrix Matrigel
scRNA-seq was used to characterise hiPSC-derived kidney organoids differentiated within fully synthetic self-assembling peptide hydrogels of variable mechanical strengths and compare these to organoids differentiated within the animal-derived matrix, Matrigel. Organoids were matured in the respectiv...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-11149 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of iPSC-derived Kidney Organoids treated with TGF-Beta 1 and GSK343 compared with vehicle treated control
This study used scRNA-seq to characterise the transcriptome in 26 day-old iPSC-derived kidney organoids, treated with TGFB1, the EzH2 inhibitor GSK343, a combination of both or a vehicle control for 48 hours (days 24-26) before harvesting. 2 organoids per condition were pooled and dissociated using ...
ORGANISM(S): Homo sapiens 
2023-04-30 | E-MTAB-11138 | biostudies-arrayexpress
TranscriptomicsSingle cell ATAC-seq of iPSC-derived Kidney Organoids treated with TGF-Beta 1 and GSK343 compared with vehicle treated control
This study used snATAC-seq to profile Chromatin accessibility in 26 day-old iPSC-derived kidney organoids, treated with TGFB1, the EzH2 inhibitor GSK343, a combination of both or a vehicle control for 48 hours (days 24-26) before harvesting. 2 organoids per condition were pooled and dissociated usin...
ORGANISM(S): Homo sapiens 
2023-04-30 | E-MTAB-11139 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lamina cribrosa cells in vitro treated with mechanical strain
The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the l...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3166 | biostudies-arrayexpress
ProteomicsDynamic protein interactions of the Polycomb Repressive Complex 2
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression. Although three subunits, EZH1/2, SUZ12 and EED, fo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080739 | MassIVE
UnknownValidating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry.
Not available
S-EPMC10830583 | biostudies-literature
UnknownThe wheat stem rust resistance gene Sr43 encodes an unusual protein kinase.
Not available
S-EPMC10260397 | biostudies-literature
UnknownReevaluation of the South Asian <i>MYBPC3</i><sup>Δ25bp</sup> Intronic Deletion in Hypertrophic Cardiomyopathy.
Not available
S-EPMC7299222 | biostudies-literature
UnknownLarge-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.
Not available
S-EPMC11906354 | biostudies-literature
UnknownPatterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry.
Not available
S-EPMC10518516 | biostudies-literature
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