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TranscriptomicsIllumina Infinium HumanMethylationEPIC DNA methylation microarray of human donor whole-blood from patients with and without Age-related Macular Degeneration
DNA methylation microarray analysis was performed on human donor whole blood samples from patients with and without AMD. A total of 30 patient samples including 16 Normal, 3 AREDS grade 2 (early AMD) and 11 AREDS grade 3 (intermediate AMD) (AMD total, n = 14) were selected. Samples were obtained fro...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11279 | biostudies-arrayexpress
TranscriptomicsAnalysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17344 | biostudies-arrayexpress
TranscriptomicsFoxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential - Differentiated vs Primary
The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice w...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-28891 | biostudies-arrayexpress
TranscriptomicsRole of ST2 expession in regulatory Tcells on muscle regneration
We describe the effects of Treg ST2 expression on muscle regeneration. We compare regneration from cryo-injured tibialis anterior muscle from Foxp3-Cre/ST2-flox vs Foxp3-Cre mice 8 days post-injury. These analyses from whole muscle provide insight into the role of muscle Tregs in the context of reg...
ORGANISM(S): Mus musculus 
2016-01-10 | E-GEOD-76697 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers from INFgamma-/- and conditional SOCS3-/- mice treated with different cytokines to study the role of SOCS3 in IL-6 signaling pathway.
Changes in mouse liver mRNA profiles following intraperitoneal cytokine injection. Either interferon-gamma-/-, albumin-cre(-) Socs3(w/fl) mice, or albumin-cre(+) Socs3(-/fl) mice were injected with either phosphate-buffered saline, interferon-gamma, or interleukin-6, and livers taken after 4h.
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-369 | biostudies-arrayexpress
TranscriptomicsExpression data of growth plate chondrocytes isolated from control or conditional Lkb1 mutant mice at postnatal day 30
We have shown that removal of Lkb1 in chondorcytes results in enchondroma-like structure in postnatal mouse long bones. To furhter understand the role of Lkb1 in this process, we performed microarrrays to compare the transcriptional profile between control and conditional Lkb1 mutant (Col2a1-Cre; Lk...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-41898 | biostudies-arrayexpress
TranscriptomicsKnockout of GPx4 gene in mouse keratinocyte
Comparative analysis of gene expression in cultured primary keratinocytes isolated from newborn control (K14-cre; GPx4fl/+) and knockout (K14-cre; GPx4fl/fl) mice. Selenoproteins are essential for skin function, as targeted abolition of selenoproteins in epidermal tissue results in newborn mice mani...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-34215 | biostudies-arrayexpress
TranscriptomicsmiR-7 blockade alters E12.5 mouse cortical mRNA levels
Purpose: To assess changes in mRNA levels due to in vivo blockade of microRNA miR-7 with a miR-7 sponge in the E12.5 mouse neocortex Methods: total RNA was isolated and sequenced from the dorsal cortex of wild-type or Emx1-Cre:miR-7-sponge transgenic mice in triplicate using an Illumina high-seq 100...
ORGANISM(S): Mus musculus 
2014-07-09 | E-GEOD-59204 | biostudies-arrayexpress
UnknownMultitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.
Not available
S-EPMC8056672 | biostudies-literature
TranscriptomicsDefective removal of ribonucleotides from DNA promotes systemic autoimmunity
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signalin...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63755 | biostudies-arrayexpress
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