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TranscriptomicsGene expression profiling of mouse luminal uterine epithelium with knockout of ALK3
Bone morphogenetic proteins (BMPs) are transforming growth factor β (TGFβ) family members that regulate the post-implantation and mid-gestation stages of pregnancy. In this study we discovered that signaling via activin-like kinase 3 (ALK3/BMPR1A), a BMP type 1 receptor, is necessary for blastocys...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-73717 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 wt and MCF7/HER2-18 xenografts
To investigate molecular mechanisms of resistance, we used two different in vivo xenograft models of estrogen receptor-positive (ER+) breast cancer, with or without HER2 over-expression (MCF7/HER2-18 and MCF7 wt, respectively). Mice with established tumors were assigned to the following treatment gr...
ORGANISM(S): Homo sapiens 
2008-12-05 | E-GEOD-8141 | biostudies-arrayexpress
TranscriptomicsGene expression and microRNA profiles of EZH2 knockdown
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-47477 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse prostate over-expressing the Notch1 intracellular domain.
Molecular signaling that regulates differentiation, survival and proliferation of the prostate luminal epithelial cells has not been thoroughly understood. Herein, we show that increased canonical Notch1 activity suppresses terminal differentiation of prostate luminal epithelial cells but is insuffi...
ORGANISM(S): Mus musculus 
2014-08-07 | E-GEOD-53036 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of ovarian tumors from mice with knockout of DICER and PTEN
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-28720 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human serious ovarian tumors and fimbria control
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-28721 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Activin-like kinase 2 knockout in mice
Implantation of an embryo in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the pregnant uterus, and BMP2 has been shown to be a...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-46689 | biostudies-arrayexpress
TranscriptomicsGene expression changes initiated by miR-34c in Dicer/Pten double knockout mouse serous epithelial cancer
miR-34c inhibits Dicer/Pten double knockout mouse serous epithelial cancer cell proliferation by inducing cell cycle arrest and apoptosis. We found that miR-34c had a more dramatic effect on inhibiting tumor cell viability than let-7b. The action of miR-34c induced tumor cell cycle arrest in G1 phas...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-57493 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of enforced HOXA1 expression in melanoma cell line
We recently reported an oncogenomics-guided screening approach designed to identify genetic drivers of early stage melanoma metastasis, and in this study we functionally validate the top-scoring candidate, homeobox transcription factor A1 (HOXA1), by demonstrating HOXA1‘s robust effects on melanom...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-37136 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of enforced HOXA1 expression in melanoma cell line (SkMel30)
We recently reported an oncogenomics-guided screening approach designed to identify genetic drivers of early stage melanoma metastasis, and in this study we functionally validate the top-scoring candidate, homeobox transcription factor A1 (HOXA1), by demonstrating HOXA1 robust effects on melanoma ce...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-40422 | biostudies-arrayexpress
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