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MetabolomicsMicrobiota-derived p-cresol and indole metabolites mediates neurotoxic gut-brain axis dysregulation in ALS
Integrated metabolomic profiling demonstrated a marked increase in microbiota-derived metabolites, particularly along aromatic amino acid pathways. Notably, p-cresol metabolites were significantly elevated in both brain and circulation, suggesting enhanced microbial phenylalanine/tyrosine metabolism...
2026-08-21 | MTBLS14404 | MetaboLights
TranscriptomicsRNA-seq of mouse brain tissue after exposure to p-cresol glucuronide
In vivo work done to determine how p-cresol glucuronide (pCG) affects integrity of the blood-brain barrier. Wild-type male C57Bl/6 mice were injected with saline or pCG, and killed 2 h after injection. Mice were transcardially perfused with 0.9% saline at 4 °C to remove circulating blood, and brains...
ORGANISM(S): Mus musculus 
2022-12-29 | E-MTAB-11340 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Danio rerio exposed to different concentrations of dinitro-ortho-cresol (DNOC) against untreated control groups
In the present study transcriptome analysis was employed to investigate the early molecular responses to exposure to DNOC (CAS 534-52-1). Zebrafish embryos were exposed to DNOC according to OECD guidelines (OECD test No. 236). At the end of exposure time (96 hours), simultaneous RNA and protein extr...
ORGANISM(S): Danio rerio 
2026-09-30 | E-MTAB-16477 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse brain tissue after exposure to p-cresol sulfate
In vivo work done to determine how p-cresol glucuronide (pCS) affects integrity of the blood-brain barrier. Wild-type male C57Bl/6 mice were injected with saline or pCS, and killed 2 h after injection. Mice were transcardially perfused with 0.9% saline at 4 °C to remove circulating blood, and brains...
ORGANISM(S): Mus musculus 
2022-12-29 | E-MTAB-12326 | biostudies-arrayexpress
GenomicsAnaerobic membrane bioreactor treating phenol and p-cresol
Anaerobic membrane bioreactor treating phenol and p-cresol Raw sequence reads
PRJNA1296805 | ENA
ProteomicsC. difficle p-cresol production
To identify the cellular localisation of the HpdBCA decarboxylase complex, a plasmid based HpdB-SNAP-tag translational fusion was constructed using a C. difficile compatible plasmid (pMTL84151) under control of the hpdBCA promoter. The hpdB coding sequence omitting the stop codon, was fused via a l...
ORGANISM(S): Clostridioides difficile ATCC 43255 
2021-11-02 | PXD028948 | Pride
Hpdbca decarboxylase 
Genomics16SrRNA from gut-microbiota of a mouse orally exposed to p-Cresol through drinkwater
16SrRNA from gut-microbiota of a mouse orally exposed to p-Cresol through drinkwater Targeted loci
PRJNA724745 | ENA
GenomicsDegradation of p-cresol, resorcinol, and phenol in anaerobic membrane bioreactors under saline conditions
Degradation of p-cresol, resorcinol, and phenol in anaerobic membrane bioreactors under saline conditions Raw sequence reads
PRJNA739995 | ENA
TranscriptomicsGene expression changes of 4,4'-thiobis(6-tert-butyl-m-cresol)-induced in renal cortex of rats
This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with 4,4'-thiobis(6-tert-butyl-m-cresol), and the gene expression...
ORGANISM(S): Rattus norvegicus 
2016-09-27 | GSE87271 | GEO
UnknownModelling the role of microbial p-cresol in colorectal genotoxicity.
Not available
S-EPMC6546321 | biostudies-literature
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