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GenomicsChIP-Seq of chromatin marks at distal enhancers in Mouse Embryonic Stem Cells and adult tissues.
Enhancers are enriched by histone H3 lysine 4 mono methylation (H3K4me1). To gain insight into the relation between enhancers and developmental state, chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) was performed in several cell types to determine the genome-wide bi...
ORGANISM(S): Mus musculus 
2010-10-31 | E-GEOD-24164 | biostudies-arrayexpress
TranscriptomicsHistone H3K27ac separates active from poised enhancers and predicts developmental state
This SuperSeries is composed of the following subset Series: GSE23907: Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data) GSE24164: ChIP-Seq of chromatin marks at distal enhancers in Mouse Embryonic Stem Cells and adult tissues. Refer to in...
ORGANISM(S): Mus musculus 
2010-10-31 | E-GEOD-24165 | biostudies-arrayexpress
TranscriptomicsHistone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data)
Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers contribute to the specific gene expression programs that determine cell state ...
ORGANISM(S): Mus musculus 
2010-10-31 | E-GEOD-23907 | biostudies-arrayexpress
GenomicsEpigenomic annotation of gene regulatory alterations during evolution of the primate brain
While genome sequencing has identified numerous non-coding alterations between primate species, which of these are regulatory and potentially relevant to the evolution of the human brain is unclear. Here, we annotate cis-regulatory elements (CREs) in the human, rhesus macaque and chimpanzee genome u...
ORGANISM(S): Macaca mulatta 
2016-01-13 | E-GEOD-67978 | biostudies-arrayexpress
GenomicsLarge-Scale Identification of Coregulated Enhancer Networks in the Adult Human Brain
The complexity of the brain and the links entailed to its functional diversity remain a major challenge of biology to understand. Distinct anatomical areas regulate a vast array of processes including organismal homeostasis, cognitive functions and susceptibility to neurological pathologies, many of...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-40465 | biostudies-arrayexpress
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