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TranscriptomicsArx acts as a key selector gene of the ventral telencephalon mainly through its repression transcriptional activity
The homeobox containing gene Arx is expressed during ventral telencephalon development and it is required for correct GABAergic interneuron tangential migration from the ganglionic eminences to the olfactory bulbs, cerebral cortex and striatum. Its human ortholog is associated with a variety of neur...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-12956 | biostudies-arrayexpress
TranscriptomicsEndometriosis transcription profiling
Endometriosis is a complex pathological condition in which multiple components are involved in the disease development and clinical outcome. Endometriosis is mainly an inflammatory codition estrogen-dependent, with unknown pathogenesis, that is characterized by dissemination of edometrium tissue in ...
ORGANISM(S): Homo sapiens 
2013-11-30 | E-GEOD-25628 | biostudies-arrayexpress
TranscriptomicsEffects of bisphenol A on gene expression in adipocytes from lean children: association to metabolic disorders
Bisphenol A (BPA) is a xenobiotic endocrine disrupting chemical. In vitro and in vivo studies indicated that BPA alters endocrine-metabolic pathways in adipose tissue increasing the risk of developing metabolic disorders. BPA effects on human adipocytes, specifically in children, are poorly investig...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-58516 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell lines from Hay Wells Syndrome-Derived TAp63alphaQ540L mutant rveals impaired transcriptional and cell growth regulatory activity
p63 mutations have been associated with several human hereditary disorders characterized by ectodermal dysplasia such as EEC syndrome, ADULT syndrome and AEC syndrome . The location and functional effects of the mutations that underlie these syndromes reveal a striking genotype-phenotype correlati...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8646 | biostudies-arrayexpress
TranscriptomicsApoptosis induced by Piroxicam/Cisplatin combined treatment is triggered by p21 in mesothelioma
Here we report that piroxicam/cisplatin combined treatment exerts an apoptotic effect on mesothelioma cells. Genome-wide transcriptome analyses lead us to identify p21 as the possible apoptosis mediator acting as downstream target of the piroxicam/cisplatin treatment. To analyze the potential therap...
ORGANISM(S): Homo sapiens 
2011-11-20 | E-GEOD-22445 | biostudies-arrayexpress
TranscriptomicsEVALUATION IN A MOUSE PROSTATE CANCER XENOGRAFT MODEL OF THE EFFECTIVENESS OF CYCLOPHOSPHAMIDE METRONOMIC REGIMEN
The aim of this study was to evaluate in a mouse prostate cancer xenograft model the effectiveness of cyclophosphamide metronomic regimen, as single agent or in combination with standard docetaxel therapy. We used a human prostate cancer cell line to establish tumours in mice and we treated the anim...
ORGANISM(S): Homo sapiens 
2012-12-30 | E-GEOD-27930 | biostudies-arrayexpress
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